Botulinum Toxin Injection in Epicardial Fat Pads To Treat Atrial Fibrillation After Cardiac Surgery



Status:Completed
Conditions:Atrial Fibrillation
Therapuetic Areas:Cardiology / Vascular Diseases
Healthy:No
Age Range:18 - 65
Updated:3/1/2014
Start Date:September 2012
End Date:December 2013
Contact:Evgeny Pokushalov, MD, PhD, FESC
Email:e.pokushalov@gmail.com
Phone:+79139254858

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Trial Summary
Trial Overview
Inclusion Criteria

Botulinum Toxin Injection in Epicardial Fat Pads Can Prevent Recurrences of Atrial Fibrillation After Cardiac Surgery: Randomized Pilot Study

The aim of this prospective randomized double-blind study was to compare the efficacy and
safety of Botulinum toxin injection in epicardial fat pads for preventing recurrences (in
early postoperative period) of atrial tachyarrhythmia in patients with paroxysmal atrial
fibrillation undergoing coronary artery bypass graft (CABG) surgery.


Inclusion Criteria:

- PAF

- Indication for CABG according to the American College of Cardiology/American Heart
Association (ACC/AHA) guidelines for CABG surgery

Exclusion Criteria:

- Previous heart surgery and AF ablation procedure

- Emergency CABG

- Unstable angina or heart failure

- Persistent AF, AF at the time of screening (planned Maze procedure or pulmonary vein
isolation)

- Use of I or III antiarrhythmic drugs within 5 elimination half-lives of the drug (or
within 2 months for amiodarone)

- Requiring concomitant valve surgery

- Left ventricle ejection fraction <35%

- Left atrial diameter >55 mm

- Unwillingness to participate
We found this trial at
1
site
The Valley Health System and Columbia University College of Physicians & Surgeons
New York, New York
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from
New York, NY
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