Diagnosing Adverse Drug Reactions Registry

Inclusion Criteria:

- Subject has care coordinated at the treating physician's outpatient clinic;

- Subject has provided written informed consent;

- Subject is taking at least three (3) regularly scheduled medications, excluding as
needed (PRN) medications, over the counter medications and nutritional supplements;
two (2) of which are known to be affected by genetic allelic variation.

- Subject's treating physician has a clinical suspicion that the subject is
experiencing adverse signs or symptoms related to a prescribed medication or is not
achieving the intended effect from the medication.

Exclusion Criteria:

- Subject has a history of chronic renal dysfunction, Chronic Kidney Disease Stage 4 or
5;

- Subject has a history of abnormal hepatic function within the last 2 years (INR >1.2
not attributable to anticoagulant medications, AST (aspartate aminotransferase) or
ALT (alanine aminotransferase) >1.5x normal, or suspected cirrhosis);

- Subject has a history of malabsorption (short gut syndrome);

- Subject has a history of any gastric or small bowel surgery;

- Subject is currently hospitalized;

- Subject is currently being treated with intravenous medication;

- Subject underwent prior pharmacogenomic testing with results reported within the last
12 months.

Subjects may be eligible within 60 days from the date of pharmacogenomic testing.