BDNF Pregnancy Study
| Status: | Completed |
|---|---|
| Conditions: | Women's Studies |
| Therapuetic Areas: | Reproductive |
| Healthy: | No |
| Age Range: | 18 - 39 |
| Updated: | 7/11/2015 |
| Start Date: | May 2012 |
| End Date: | May 2015 |
| Contact: | Jessica L Snell, M.S. |
| Email: | jessnell@mail.med.upenn.edu |
| Phone: | (215) 573-8880 |
Peripheral Serum BDNF Levels and Poor Birth Outcomes
The purpose of this study is to evaluate the correlation between varying levels of
neuropeptides and birth outcomes. Neuropeptides are substances (proteins) produced in the
body in very small amounts but without which the nervous system cannot function properly,
and which might have a role in the health of a newborn. As part of this study, we are
collecting blood samples from pregnant women.
Neuropeptides and hormones can be measured in blood. This study will involve three blood
draws from the participants arm. Demographic information will also be requested, and
participants will be asked to complete questionnaires about their mood and personal
experiences at each visit.
Our hypothesis is that participants with lower levels of brain-derived neurotrophic factor
(BDNF) will be at increased risk for poor birth outcomes.
neuropeptides and birth outcomes. Neuropeptides are substances (proteins) produced in the
body in very small amounts but without which the nervous system cannot function properly,
and which might have a role in the health of a newborn. As part of this study, we are
collecting blood samples from pregnant women.
Neuropeptides and hormones can be measured in blood. This study will involve three blood
draws from the participants arm. Demographic information will also be requested, and
participants will be asked to complete questionnaires about their mood and personal
experiences at each visit.
Our hypothesis is that participants with lower levels of brain-derived neurotrophic factor
(BDNF) will be at increased risk for poor birth outcomes.
This prospective, non-randomized trial will evaluate peripheral serum blood levels of BDNF
in participants recruited from previously identified University of Pennsylvania obstetrics
and gynecological (OB/GYN) clinics. A total of 100 pregnant subjects will be recruited
consecutively and evaluated in the first and third trimester of their pregnancy as well as
within a month after delivery.
The entire project will take one year.
in participants recruited from previously identified University of Pennsylvania obstetrics
and gynecological (OB/GYN) clinics. A total of 100 pregnant subjects will be recruited
consecutively and evaluated in the first and third trimester of their pregnancy as well as
within a month after delivery.
The entire project will take one year.
Inclusion Criteria:
- Participants must be at least 18 years old and being treated at an outpatient OB/GYN
clinic;
- At least 8 weeks pregnant;
- Capable of giving informed consent.
Exclusion Criteria:
- Participants younger than 18 years of age;
- History of preterm birth;
- Psychiatric medications during current pregnancy;
- Participants with a history of hematologic disorders;
- Participants who refuse informed consent.
We found this trial at
4
sites
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Philadelphia, Pennsylvania 19104
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