Functional Differences in Effortful Control
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Healthy Studies |
| Therapuetic Areas: | Other |
| Healthy: | No |
| Age Range: | 18 - 35 |
| Updated: | 11/29/2018 |
| Start Date: | October 2013 |
| End Date: | May 2019 |
The purpose of this study is to learn more about the brain circuits involved with effortful
control in healthy adult participants. Study participants will be given either
methylphenidate (also known as 'Ritalin')which is an FDA approved, most widely-used
medication given to those diagnosed with Attention Deficit Hyperactivity Disorder (ADHD)or a
placebo, which is a sugar pill. Each participant will also perform some computer tasks that
have been shown in previous studies to require effortful control while undergoing an fMRI
(functional Magnetic Resonance Imaging) which takes a special kind of picture of the brain.
Our goal is to learn more about the brain mechanisms by which methylphenidate improves
effortful control.
control in healthy adult participants. Study participants will be given either
methylphenidate (also known as 'Ritalin')which is an FDA approved, most widely-used
medication given to those diagnosed with Attention Deficit Hyperactivity Disorder (ADHD)or a
placebo, which is a sugar pill. Each participant will also perform some computer tasks that
have been shown in previous studies to require effortful control while undergoing an fMRI
(functional Magnetic Resonance Imaging) which takes a special kind of picture of the brain.
Our goal is to learn more about the brain mechanisms by which methylphenidate improves
effortful control.
This study involves two total visits. All visits are scheduled at the Rachel Upjohn Building
on East Medical Campus of the University of Michigan. Participation in this study will end
once the participant has completed both study visits which are a total of 4 hours. The first
visit will require one to complete various questionnaires regarding behavior and general
health and takes about 1 hour to complete. The second visit will be scheduled approximately 2
to 7 days after the first study visit and includes the fMRI scanning session. The second
visit will last about 3 hours.
on East Medical Campus of the University of Michigan. Participation in this study will end
once the participant has completed both study visits which are a total of 4 hours. The first
visit will require one to complete various questionnaires regarding behavior and general
health and takes about 1 hour to complete. The second visit will be scheduled approximately 2
to 7 days after the first study visit and includes the fMRI scanning session. The second
visit will last about 3 hours.
Inclusion Criteria:
- Right-handedness
Exclusion Criteria:
- Any clinically significant personal or family history of cardiac problems
- Any current Axis I psychiatric disorder (diagnosis as verified by the Structured
Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders-IV)
- A previous adequate trial with methylphenidate (Ritalin)
- Currently taking any psychoactive medications
- Any clinically significant medical condition
- Any clinically significant neurological problem (seizures, tics, serious head injury)
- Contraindications to MRI (metal objects in body or claustrophobia)
- Currently pregnant or lactating
- Alcohol or substance abuse (current or in the past 2 years)
- Left-handedness or ambidextrous
- Liver or kidney disease
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