Markers of Alzheimers Disease and Cognitive Outcomes After Perioperative Care



Status:Active, not recruiting
Conditions:Alzheimer Disease, Cognitive Studies, Psychiatric
Therapuetic Areas:Neurology, Psychiatry / Psychology
Healthy:No
Age Range:60 - Any
Updated:12/26/2018
Start Date:November 2013
End Date:February 2019

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Trial Summary
Trial Overview
Inclusion Criteria
This study will examine the hypothesis that changes in the cognition (i.e. thinking and
memory) after anesthesia and surgery are correlated with changes in markers of Alzheimers
Disease in the fluid around the brain and spinal cord (i.e. cerebrospinal fluid, or CSF),
and/or changes in brain connectivity. The investigators will also examine whether different
types of anesthesia have different effects on these CSF markers of Alzheimers disease, or
different effects on thinking and memory after anesthesia and surgery, or differential
effects on the correlation between cognitive changes and CSF marker changes.


Inclusion Criteria:

- Surgical patients 60 years of age or older

- Surgery scheduled to last at least 2 hours (including time for anesthesia induction,
etc)

- English speaking ability.

- Ability to give informed consent

Exclusion Criteria:

- Inmate of a correctional facility (i.e. prisoners).

- Pregnancy

- Documented or suspected family or personal history of malignant hyperthermia.

- Patient unable to receive either propofol or isoflurane due to allergy or other
specific contraindication.
We found this trial at
1
site
Duke Univ Med Ctr
2301 Erwin Rd
Durham, North Carolina 27710
919-684-8111
Principal Investigator: Miles Berger, MD, PhD
Duke Univ Med Ctr As a world-class academic and health care system, Duke Medicine strives...
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Durham, NC
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