Study of Cabozantinib in Combination With Abiraterone in Chemotherapy-Naïve Subjects With Bone-Metastatic Castration-Resistant Prostate Cancer

Inclusion Criteria:

- Histologically or cytologically confirmed adenocarcinoma of the prostate.

- Must be surgically or medically castrated (serum testosterone levels less than or
equal to 50 ng/dL)

- Must have castration-resistant prostate cancer (CRPC) with disease progression during
LHRH therapy or after a surgical bilateral orchiectomy.

- Bone metastasis related to prostate cancer

- Adequate organ and marrow function

- Capable of understanding and complying with the protocol requirements and signed the
informed consent document

- Sexually active subjects and their partners must agree to use medically accepted
methods of barrier contraception (eg, male condom or female condom) as well as one
other medically accepted method of contraception during the course of the study
treatment and for 4 months after the last dose of study treatment.

Exclusion Criteria:

- Any prior treatment with abiraterone, enzalutamide, or any investigational agents
blocking androgen receptor (AR) or androgen synthesis.

- Any prior treatment with cabozantinib or participation in a prior clinical trial of
cabozantinib.

- Any prior cytotoxic therapy (including estramustine) or biologic therapy for the
treatment of prostate cancer (a few exceptions will be allowed)

- Any prior radionuclide therapy (eg, samarium 153, strontium 89, alpharadin)

- Use of investigational agent within 28 days

- Any pathological finding consistent with small cell carcinoma of the prostate

- Known brain metastases or cranial epidural disease

- Diagnosis of another malignancy within 2 years, except for superficial non-melanoma
skin cancers, or localized, low grade tumors deemed cured and not treated with
systemic therapy