Developing a Discrimination Model to Diagnose ALS

Early diagnosis and lack of understanding of the pathophysiology of ALS remain a significant
obstacle to making a timely intervention to help patients suffering from this fatal disease.
We envision a future in which neuroimaging techniques will be a critical tool in the
diagnostic work-up of ALS. Advanced neuroimaging techniques offer great potential in
identifying central nervous system metabolite and cellular alterations in ALS. We propose an
innovative approach to combine complementary advanced MRI techniques to interrogate brain
chemistry (MRS), brain microstructure (DTI) and brain function (fcMRI) and develop a
clinically relevant discriminatory disease model.

Inclusion Criteria:

1. 18 years of age or older

2. subjects with ALS (amyotrophic lateral sclerosis)

3. healthy subjects -

Exclusion Criteria:

1. Active substance abuse

2. Has co-morbid psychiatric disease

3. Has opportunistic CNS (central nervous system) infection

4. Has a history of head injury

5. Has a contraindication for MRI (e.g. cardiac pacemaker, ferromagnetic or metallic
implants)

6. Pregnant