Phase 3 Study of EBI-005 in Dry Eye Disease

Inclusion Criteria:

- Give written informed consent and any authorizations required by local law (e.g.,
Protected Health Information waiver) prior to performing any study procedures;

- Are ≥ 18 years of age;

- Are willing and able to follow instructions and can be present for the required study
visits for the duration of the study;

- Have a history of dry eye disease (DED) in both eyes supported by a previous clinical
diagnosis

- Have normal lid anatomy.

- If female and of child bearing potential, she must not be not pregnant or lactating
and not sexually active (abstinent) within 14 days prior to Visit 1

Exclusion Criteria:

- Have signs of infection (i.e., fever or current treatment with antibiotics)

- Have been exposed to an investigational drug/device within the preceding 30 days

- Be an employee of the site that is directly involved in the management,
administration, or support of the study, or be an immediate family member of the same

- Be unwilling to or unable to comply with the study