EoE(Eosinophilic Esophagitis)
| Status: | Completed |
|---|---|
| Conditions: | Gastrointestinal, Gastrointestinal |
| Therapuetic Areas: | Gastroenterology |
| Healthy: | No |
| Age Range: | 8 - 18 |
| Updated: | 12/17/2016 |
| Start Date: | January 2014 |
| End Date: | April 2016 |
Quantitative MRI Evaluation of Esophageal Remodeling/Response to Treatment in Children and Adolescents With Eosinophilic Esophagitis Presenting With Dysphagia
To evaluate quantitative magnetic resonance imaging(MRI) as a potential non-invasive,
radiation-free diagnostic tool for evaluating esophageal wall remodeling (thickness and
stiffness) and response to treatment in children and adolescents with newly diagnosed
eosinophilic esophagitis (EoE) presenting with dysphagia (difficulty swallowing) and food
impaction.
radiation-free diagnostic tool for evaluating esophageal wall remodeling (thickness and
stiffness) and response to treatment in children and adolescents with newly diagnosed
eosinophilic esophagitis (EoE) presenting with dysphagia (difficulty swallowing) and food
impaction.
Eosinophilic esophagitis(EoE) is a form of chronic inflammation affecting the esophagus
which often results in wall thickening and esophageal stiffening and is associated with
complications, such as esophageal tears and strictures (narrowings). Chronic dysphagia and
acute food impaction (swallowed food stuck in the esophagus) are common symptoms of EoE and
are associated with esophageal wall thickening and stiffness.
Current diagnostic techniques such as endoscopy with biopsy give only limited information
about changes in the esophageal wall in eosinophilic esophagitis(EoE). In routine clinical
practice, repeat endoscopic evaluation with biopsy is commonly performed about 3-6 months
after initial therapy for eosinophilic esophagitis(EoE). However, follow-up endoscopy with
biopsy has drawbacks as it is invasive, costly and typically requires deep sedation or
general anesthesia.
We propose to evaluate quantitative MRI as a potential non-invasive diagnostic option for
evaluating esophageal wall remodeling in patients with eosinophilic esophagitis(EoE).
which often results in wall thickening and esophageal stiffening and is associated with
complications, such as esophageal tears and strictures (narrowings). Chronic dysphagia and
acute food impaction (swallowed food stuck in the esophagus) are common symptoms of EoE and
are associated with esophageal wall thickening and stiffness.
Current diagnostic techniques such as endoscopy with biopsy give only limited information
about changes in the esophageal wall in eosinophilic esophagitis(EoE). In routine clinical
practice, repeat endoscopic evaluation with biopsy is commonly performed about 3-6 months
after initial therapy for eosinophilic esophagitis(EoE). However, follow-up endoscopy with
biopsy has drawbacks as it is invasive, costly and typically requires deep sedation or
general anesthesia.
We propose to evaluate quantitative MRI as a potential non-invasive diagnostic option for
evaluating esophageal wall remodeling in patients with eosinophilic esophagitis(EoE).
Inclusion Criteria:
1. Pediatric patients ages 8 to 18 years of age.
2. Pediatric patients with dysphagia(difficulty swallowing) or an episode of food
impaction.
3. Pediatric patients newly diagnosed with Eosinophilic Esophagitis -
Exclusion Criteria:
1. Are not able to undergo an MRI without needing sedation or general anesthesia
2. Are allergic to gadolinium-based contrast material
3. Have an ongoing acute kidney injury
4. Have chronic kidney disease with an estimated glomerular filtration rate(eGFR)of <40
ml/min.
5. Have a presence of eosinophilia involving the stomach and/or esophagus.
6. Have a prior history of caustic ingestion
7. Have a prior history of esophageal surgery, including history of tracheoesophageal
fistula.
8. Have known celiac disease
9. Have known Crohn's disease
10. Have known malignancy
11. Have hypereosinophilic syndrome
12. Have recent history of parasitic infection
13. Have known inflammatory bowel disease -
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