Impacts of Exercise on Prognostic Biomarkers in Lung Cancer Patients
| Status: | Completed |
|---|---|
| Conditions: | Lung Cancer, Lung Cancer, Cancer, Cancer, Cancer, Cancer, Cancer, Cancer, Healthy Studies |
| Therapuetic Areas: | Oncology, Other |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/21/2016 |
| Start Date: | December 2013 |
| End Date: | February 2016 |
This randomized pilot clinical trial studies exercise intervention in improving quality of
life and exercise capacity and reducing inflammation and oxidative stress in patients with
lung cancer and their support persons. Exercise therapy may help improve quality of life,
may increase exercise capacity, and may reduce inflammation and oxidative stress in patients
with lung cancer and their supporters.
life and exercise capacity and reducing inflammation and oxidative stress in patients with
lung cancer and their support persons. Exercise therapy may help improve quality of life,
may increase exercise capacity, and may reduce inflammation and oxidative stress in patients
with lung cancer and their supporters.
PRIMARY OBJECTIVES:
I. Determine the effect of an eight-week exercise intervention on biomarkers of
inflammation, oxidative stress, exercise capacity, and quality of life in lung cancer
patients.
SECONDARY OBJECTIVES:
I. Determine the effect of an eight-week exercise intervention on markers of stress and
quality of life in the support person of lung cancer patients.
OUTLINE: Participants are randomized to 1 of 2 arms.
ARM A: Patients and their support persons undergo a supervised combined aerobic exercise
comprising walking, cycling, or video-based aerobics and strength training using resistance
bands for 40 minutes 2 days a week at the University of Wisconsin Hospital and Clinic (UWHC)
and 3 days a week at home over 8 weeks.
ARM B: Patients and their support persons undergo the usual care over 8 weeks.
I. Determine the effect of an eight-week exercise intervention on biomarkers of
inflammation, oxidative stress, exercise capacity, and quality of life in lung cancer
patients.
SECONDARY OBJECTIVES:
I. Determine the effect of an eight-week exercise intervention on markers of stress and
quality of life in the support person of lung cancer patients.
OUTLINE: Participants are randomized to 1 of 2 arms.
ARM A: Patients and their support persons undergo a supervised combined aerobic exercise
comprising walking, cycling, or video-based aerobics and strength training using resistance
bands for 40 minutes 2 days a week at the University of Wisconsin Hospital and Clinic (UWHC)
and 3 days a week at home over 8 weeks.
ARM B: Patients and their support persons undergo the usual care over 8 weeks.
Inclusion Criteria:
- LUNG CANCER PATIENTS: A confirmed diagnosis of any stage lung cancer (non-small cell
lung cancer [NSCLC] or small cell lung cancer [SCLC])
- LUNG CANCER PATIENTS: Can be receiving any type of treatment (chemotherapy, radiation
therapy, both or neither) are eligible
- LUNG CANCER PATIENTS: Able to understand and read in English sufficiently to
adequately complete informed consent to participate and to complete the
questionnaires
- LUNG CANCER PATIENTS: For patients treated with curative intent, and who have not
relapsed, they must be within 1 year of their diagnosis of lung cancer (determined by
date of diagnostic pathology sample)
- SUPPORT PERSONS: Able to understand and read in English sufficiently to adequately
complete informed consent to participate and to complete the questionnaires
Exclusion Criteria:
- LUNG CANCER PATIENTS: Symptomatic heart disease including congestive heart failure or
arrhythmia
- LUNG CANCER PATIENTS: Documented myocardial infarction in the last three months
- LUNG CANCER PATIENTS: Central nervous system (CNS) metastases that results in
impaired ability to participate in an exercise program at the discretion of the study
physician
- LUNG CANCER PATIENTS: Any psychological or physical disease that would impair or
prevent participation in an exercise program at the discretion of the study physician
- LUNG CANCER PATIENTS: Cognitive or reading impairments that would preclude them from
completing questionnaires
- LUNG CANCER PATIENTS: Current participation in an exercise program
- SUPPORT PERSONS: Symptomatic heart disease including congestive heart failure or
arrhythmia
- SUPPORT PERSONS: Documented myocardial infarction in the last three months
- SUPPORT PERSONS: Cognitive or reading impairments that would preclude them from
completing questionnaires
We found this trial at
2
sites
University of Wisconsin-Madison In achievement and prestige, the University of Wisconsin-Madison has long been recognized...
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