Alzheimer's Prevention Through Exercise

Inclusion Criteria:

- Clinical Dementia Rating 0 (nondemented)

- Age 65 or older

- Florbetapir PET evidence of cerebral amyloidosis

- Sedentary or underactive by the Telephone Assessment of Physical Activity

- Stable doses of medications for 30 days.

- Clinician judgment regarding subject's health status and likelihood to successfully
complete the 1-year exercise intervention

Exclusion Criteria:

- Clinically significant major psychiatric disorder (e.g., Major Depressive Disorder)
according to standard criteria or significant psychiatric symptoms that could impair
the completion of the study

- Clinically-significant systemic illness that may affect safety or completion of the
study

- History of clinically-evident stroke

- Clinically-significant infection within the last 30 days

- Active cardiac condition (e.g. angina, myocardial infarction, atrial fibrillation) or
pulmonary condition in the past 2 years that, in the investigator's opinion, could
pose a safety risk to the participant—unless cleared for exercise by the participant's
primary care physician or cardiologist.

- Uncontrolled hypertension within the last 6 months

- History of cancer in the last 5 years (except non-metastatic basal or squamous cell
carcinoma)

- History of drug or alcohol abuse as defined by DSM-IV criteria within the last 2 years

- Insulin-dependent diabetes mellitus

- Significant pain or musculoskeletal disorder prohibiting participation in an exercise
program

- Unwillingness to undergo or contraindication to brain MRI scan.

- History within the last 5 years of primary or recurrent malignant disease with the
exception of resected localized cutaneous squamous cell carcinoma, basal cell
carcinoma, cervical carcinoma, or prostate cancer.