1303GCC: Trastuzmab & Pertuzumab With Hormonal Therapy or Chemotherapy in Women Aged 60 and Over.
| Status: | Terminated |
|---|---|
| Conditions: | Breast Cancer, Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 60 - Any |
| Updated: | 2/9/2018 |
| Start Date: | January 2014 |
| End Date: | January 2016 |
1303GCC: Phase II Study of Trastuzumab and Pertuzumab Alone and in Combination With Hormonal Therapy or Chemotherapy in Women Aged 60 and Over With HER2/Neu Overexpressed Locally Advanced and/or Metastatic Breast Carcinoma
This is a phase II study that combines Trastuzumab with Pertuzumab to see how it works in
women age greater than 60 who have been diagnosed with HER2/neu overexpressed locally
advanced and/or metastatic breast carcinoma.
women age greater than 60 who have been diagnosed with HER2/neu overexpressed locally
advanced and/or metastatic breast carcinoma.
Currently available standard therapies for HER2 overexpressed metastatic breast cancers (MBC)
include treatments with chemotherapy or hormonal therapy, alone or in combination with
medications that target HER2 gene, such as Trastuzumab or Pertuzumab. This study will examine
the effect of treating HER2 overexpressed MBC with the combination of Trastuzumab plus
Pertuzumab, without hormonal or chemotherapy, as a first line treatment. If patients progress
on this treatment, they will receive hormonal or chemotherapy in addition to the Trastuzumab
plus Pertuzumab treatment. The objective is to see how the overall response rate for this
treatment compares to other first line treatments in the same patient population.
include treatments with chemotherapy or hormonal therapy, alone or in combination with
medications that target HER2 gene, such as Trastuzumab or Pertuzumab. This study will examine
the effect of treating HER2 overexpressed MBC with the combination of Trastuzumab plus
Pertuzumab, without hormonal or chemotherapy, as a first line treatment. If patients progress
on this treatment, they will receive hormonal or chemotherapy in addition to the Trastuzumab
plus Pertuzumab treatment. The objective is to see how the overall response rate for this
treatment compares to other first line treatments in the same patient population.
Inclusion Criteria:
1. Women ≥60 Years of Age.
2. Histologically confirmed, locally advanced (T4 primary tumor and stage IIIB or IIIC
disease) or metastatic breast cancer that progressed after treatment with standard
treatment regimens in the adjuvant or neoadjuvant setting.
3. Prior treatment with trastuzumab and/or lapatinib in the neo-adjuvant or adjuvant
setting is allowed but not required. Lapatininb has to be discontinued > 21 days
before the initiation of the T+P study treatments.
4. Up to 3 prior chemo regimens for treatment of metastatic disease are allowed as long
as the study subject is acceptable for study treatment with chemo required on this
study in cohort 2 at progression on T+P.
5. Patients may have had prior hormonal therapy with any hormonal agents as per section
3.1.5 of this protocol.
6. Zometa or denosumab can be continued as per standard of care as long as started before
the study treatment is started.
7. HER2 positive breast cancer, as defined in Section 3.3 of this protocol
8. Must have measurable or evaluable disease according to RECIST 1.1 criteria.
9. Lab values obtained ≤7 days prior to registration as indicated in 3.1.9 of this
protocol.
10. ECOG Performance Status (PS) of 0, 1 or 2.
11. LVEF at least 50% as determined by MUGA or ECHO.
12. Life expectancy >3 months.
13. Written informed consent.
14. Willingness to return to study site for treatment and follow-up.
15. Normal QTc interval defined on EKG as QTc ≤ 440 msec.
16. Postmenopausal women defined in section 3.1.16 of this protocol.
Exclusion Criteria:
1. Stage III or IV cancer, other than breast cancer, in ≤5 years prior to registration.
2. Actively being treated for other malignancy.
3. New York Heart Association Class III or IV cardiovascular disease.
4. History of coronary heart failure (CHF)
5. Current use of drugs known to prolong the QTc interval including Class Ia and III
antiarrhythmics or history of congenital long QTc syndrome.
6. Evidence of active brain metastasis including leptomeningeal involvement.
7. Major surgery, chemotherapy, hormonal or immunologic therapy ≤3 weeks prior to
registration.
8. Radiotherapy ≤3 weeks prior to registration, except if to a non-target lesion only.
9. Prior treatment with Pertuzumab, Eribulin, Fulvestrant or Anastrozole.
10. Uncontrolled illness.
11. Co-morbid systemic illnesses or other severe concurrent disease. See section 3.2.11.
12. Currently receiving treatment in a different clinical study in which investigational
procedures are performed or investigational therapies are administered.
13. Immunocompromised patients (other than that related to the use of corticosteroids)
including patients known to be HIV positive.
14. International normalized ratio (INR), activated partial thromboplastin time (aPTT) or
partial thromboplastin time (PTT) >1.5 × ULN (unless on anticoagulation medication)
15. Receipt of intravenous (IV) antibiotics for infection within 7 days prior to
enrollment into the study.
16. Current chronic daily treatment with corticosteroids. See section 3.2.16 of this
protocol.
17. Known hypersensitivity to any of the study treatments or to excipients of recombinant
human or humanized antibodies.
18. History of receiving any investigational treatment within 28 days prior to enrollment
into the study.
19. Assessed by the investigator to be unable or unwilling to comply with the requirements
of the protocol.
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