Effect of Exercise on Metabolic Health
| Status: | Recruiting |
|---|---|
| Conditions: | Obesity Weight Loss |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | 18 - 40 |
| Updated: | 7/5/2018 |
| Start Date: | November 2013 |
| End Date: | November 2025 |
| Contact: | Suzette Howton, RD |
| Email: | suzetter@med.umich.edu |
| Phone: | 734-647-9850 |
Effect of Exercise on Novel Insulin Signaling Events in Human Muscle
One of the main objectives of this study will be to assess potential differences in important
risk factors associated with Metabolic Syndrome in overweight adults who do not participate
in a regular exercise program compared with overweight individuals who do exercise regularly.
In addition, we will determine the effects of a single, modest session of exercise on the
body's ability to control blood sugar and regulate fat metabolism in obese sedentary adults
vs. obese adults who live a physically active lifestyle. Our study focuses on identifying
mechanisms responsible for improved insulin action related to regular exercise and to provide
novel targets for preventing and treating type 2 diabetes.
risk factors associated with Metabolic Syndrome in overweight adults who do not participate
in a regular exercise program compared with overweight individuals who do exercise regularly.
In addition, we will determine the effects of a single, modest session of exercise on the
body's ability to control blood sugar and regulate fat metabolism in obese sedentary adults
vs. obese adults who live a physically active lifestyle. Our study focuses on identifying
mechanisms responsible for improved insulin action related to regular exercise and to provide
novel targets for preventing and treating type 2 diabetes.
Inclusion Criteria:
- Body Mass Index [BMI] = 30-45 kg/m2, fasting blood glucose concentration must be < or
= to125 mg/dl, Hematocrit > or = to 34%, all women must be pre-menopausal
Exclusion Criteria:
- pregnancy or actively breastfeeding, weight instability (> or = to ± 5 lbs in the past
month) evidence of cardiovascular or metabolic diseases, taking medications know to
affect lipid and/or glucose metabolism.
We found this trial at
1
site
Ann Arbor, Michigan 48109
Principal Investigator: Jeffrey F Horowitz, PhD
Phone: 734-647-9850
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