Initial Human Validation of Simultaneous Dual-Tracer Cardiac PET Imaging

Positron emission tomography (PET) scans can be used to evaluate whether parts of the heart
muscle (myocardium) are alive but receiving inadequate blood supply. This information can be
helpful in identifying the best course of treatment. This type of study involves the use of
two radiotracers: rubidium-82 (to measure blood flow) and 18F-fluorodeoxyglucose or FDG (to
measure whether heart muscle cells are alive). Currently, each of these radiotracers is
imaged at separate times, several hours apart. The purpose of this study is to evaluate
methods that could allow the entire study to be performed at one time.

Inclusion Criteria:

1. 18 years of age or older

2. Patients referred for clinically indicated positron emission tomography (PET)
viability assessment with rubidium-82 rest perfusion imaging and
18F-fluorodeoxyglucose (FDG) metabolic imaging.

Exclusion Criteria:

1. Need for stress perfusion imaging

2. Claustrophobia which would prevent positron emission tomography (PET) imaging.

3. Inability to lie flat with arms positioned next to the head for approximately 20
minutes.

4. Clinical instability such as uncontrolled, potentially life threatening arrhythmias
or heart failure requiring mechanical support or infusions of inotropic or
vasopressor agents.

5. Pregnancy