Dosage and Predictors of Naming Treatment Response in Aphasia

Language and communicative impairments following stroke (aphasia) affect more than 30% of
stroke survivors, with an incidence of over 180,000 new cases annually. The consequences of
aphasia are far reaching and can affect psychosocial adjustment, family role participation,
vocational opportunities, and the ability to function independently in society. Recent
estimates suggest that VHA outpatient clinics see 2000 new cases of aphasia each year,
meaning that approximately 20,000 enrolled VHA patients and 100,000 United States Veterans
are currently living with the condition. In response to this need, the VA Pittsburgh
Healthcare System Geriatric Research, Education, and Clinical Center (GRECC) initiated the
Program for Intensive Residential Aphasia Treatment and Education (PIRATE) in January 2009.
PIRATE is a clinical demonstration project that provides approximately 100 hours of
cognitive-linguistically oriented aphasia treatment to community dwelling Veterans over a
4-week period. PIRATE currently serves 18 Veterans per year in bi-monthly sessions. Resource
limitations associated with PIRATE and aphasia treatment in general require that treatments
be offered in the most cost-effective doses to those Veterans most likely to benefit from
them.

This treatment-effectiveness research study addresses these issues by examining the
dose-response relationship for semantically-oriented naming treatment, and identifying
cognitive, psycholinguistic and neuroanatomical predictors of treatment success. Study
participants (n=60, over a 4-year period) will be recruited nationwide from Veterans enrolled
in PIRATE. They will have their naming performance measured prior to PIRATE entry, during
each week of treatment, and at program exit/follow-up. A battery of cognitive measures and
structural magnetic resonance images of their brains will also be collected prior to
treatment. Participants' performance on trained and untrained lexical items and a
standardized measure of naming performance will be compared across time intervals to specify
the therapy amounts for which maximum treatment benefits are achieved. Their treatment
outcomes will also be correlated with specific cognitive test scores and the location and
extent of their brain lesions to identify cognitive and neurological markers predictive of
positive treatment response. Treatment response will also be compared across participants
with different psycholinguistic profiles, to determine which groups of patients show greatest
benefit from semantically-oriented naming treatment.

This study should provide answers to two interlocking questions: for whom is aphasia therapy
most effective, and how much of it is needed to optimize treatment outcomes. These answers
have the potential to set transformative new standards for how aphasia treatment is delivered
within VHA and to stroke survivors with aphasia more broadly.

Inclusion Criteria:

- All study participants will be community-dwelling adults with aphasia.

- Both Veterans and non-Veterans who are able to arrange daily transportation to and
from the campus of the VA Pittsburgh Healthcare System (VAPHS), and who do not require
housing, may be eligible to be study participants.

- In addition, Veterans who are accepted into the Program for Intensive Residential
Aphasia Treatment and Education (PIRATE) of VAPHS may be eligible to participate.

- PIRATE participants are Veterans who are referred nationally to VAPHS.

- Aphasia diagnosis is provided by the referring medical provider, based on
performance on standardized aphasia-assessment measures, and will be verified by
PIRATE staff prior to enrollment. Diagnosis will be based on clinical impression
and performance on the Comprehensive Aphasia Test (CAT).

Study participants must also meet the following inclusion criteria:

- 18 years of age or older

- Eligible for participation in the standard PIRATE program

- Aphasia due to unilateral left hemisphere stroke equal to or more than 6 months post
onset

- Overall CAT mean language modality t-score of less than or equal to 70

- CAT naming modality t-score greater than or equal to 40

- No progressive neurological disease or prior central nervous system injury/disorder

- No severe motor speech disorders (apraxia and/or dysarthria)

- Learned English as a first language

- Investigators able to construct lists of sufficient treatment targets and
generalization probes based on performance on naming assessments

Exclusion Criteria:

Since all study candidates must be present on the VAPHS campus for treatment, and must
undergo intensive speech-language therapy (up to 5 hours per day for 4 weeks), the
following exclusionary criteria apply to all participants:

- Inability to carry out activities of daily living necessary for self-care during the
time they are present on the VAPHS campus

- Lack of physical independence which would interfere with their ability to be present
on the VAPHS campus

- History of progressive neurological disease

- History of drug or alcohol dependence that is not currently stable/medically managed

- Inability to tolerate intensive treatment as determined by previous therapy
experiences and tolerance of the intensive initial evaluation (2 days of testing)

In addition, participants who are enrolling in the study through the PIRATE program have
the following exclusion criteria apply:

- Inability to carry out activities of daily living necessary for self-care as
determined by an occupational therapy assessment prior to program entry

- Lack of physical independence

- History of significant mood or behavioral disorder that is not currently
stable/medically managed

- History of progressive neurological disease

- History of drug or alcohol dependence that is not currently stable/medically managed

- Inability to tolerate intensive treatment as determined by previous therapy
experiences and tolerance of the intensive initial evaluation (2 days of testing)

- Medical conditions which would preclude independent living as determined by the
medical assessment provided by a VAPHS physician prior to program entry