Neuroimaging Study of Factors Related to Exercise

This is a nonrandomized trial with groups being defined by BMI and adherence status to the
exercise intervention.

Inclusion Criteria:

- BMI >25 to < 40±1

- Must live in the Greater Kansas City area for at least 1 year

- Willing to exercise

- Provide written approval from a licensed physician that they are healthy enough to
participate in a program of moderate physical activity and maximum O2 testing

- All participants must be sedentary except for casual recreation such as softball,
bowling, etc.

Exclusion Criteria:

- Color-blindness

- Left-handedness

- Any diagnosed neurological disorder or conditions that preclude MRI scanning (e.g.,
metal in body)

- Participation in a research project involving weight loss or physical activity in the
previous 6 months

- Subjects who smoke

- Subjects use medications that affect metabolism (i.e. thyroid, beta blockers), use
medications that affect appetite (i.e. Meridia) or cannot exercise (i.e. walk)

- Participants will be excluded by study personnel following interview if they exhibit
eating disorders, binge eating, depression or drug addiction

- Metabolic disease that would affect energy balance (e.g. diabetes mellitus or
hypothyroidism)

- Pregnant during the previous 6 months, are lactating, or plan pregnancy within 12
months

- Individuals who are not weight stable (± 4.5kg) within the previous year.

- Serious medical risks such as type 1-diabetes, cancer, recent cardiac event (i.e.
heart attack, angioplasty, etc.)

- High blood pressure

- Current use of smoking/tobacco products or initiation of the use of smoking/tobacco
products during the study and alcohol abuse and any history of dependence

- Subject IQ is less that 80

- Reported radiation exposure from CT, PET, fluoroscopic or nuclear medicine studies
within the previous year, or other radiation exposure at the discretion of the PI