Effects of Coenzyme Q10 in Progressive Supranuclear Palsy (PSP)
| Status: | Completed |
|---|---|
| Conditions: | Parkinsons Disease, Neurology |
| Therapuetic Areas: | Neurology |
| Healthy: | No |
| Age Range: | 30 - Any |
| Updated: | 10/14/2017 |
| Start Date: | September 2006 |
| End Date: | January 2015 |
Effects of Coenzyme Q10 in Progressive Supranuclear Palsy (PSP): A Multicenter, Randomized, Placebo-controlled, Double Blind Study
The clinical syndrome of PSP responds poorly to all available forms of therapy used in
Parkinson's Disease (PD). Currently, no effective treatment exists. Coenzyme Q10 in high
doses has been shown to be a beneficial therapy in PD and might possibly be a beneficial
therapy for PSP. This study will compare the efficacy, safety and tolerability of Coenzyme
Q10 versus placebo in patients with atypical parkinsonian syndrome, progressive supranuclear
palsy (PSP).
Parkinson's Disease (PD). Currently, no effective treatment exists. Coenzyme Q10 in high
doses has been shown to be a beneficial therapy in PD and might possibly be a beneficial
therapy for PSP. This study will compare the efficacy, safety and tolerability of Coenzyme
Q10 versus placebo in patients with atypical parkinsonian syndrome, progressive supranuclear
palsy (PSP).
The study is designed as a multicenter randomized, placebo-controlled, double blind trial. Up
to 60 patients with PSP will be enrolled at several centers in the United States
to 60 patients with PSP will be enrolled at several centers in the United States
Inclusion Criteria:
- Patients fulfilling the diagnostic criteria of PSP/diagnosed within the past 5 years
- Either vertical supranuclear palsy or both slowing of vertical saccades
- Prominent postural instability with falls in the first year of disease onset
- No evidence of other diseases that could explain the foregoing features
Exclusion Criteria:
- Current or previous therapeutic use of CoQ10
- Parkinsonism due to drugs
- History of pallidotomy, thalamotomy, active deep brain stimulator or fetal tissue
transplant
- History of active epilepsy, stroke, structural brain disease
- Use of methylphenidate hydrochloride, cinnarizine, reserpine, amphetamines, or
monoamine oxidase-A inhibitors within 3 months before the baseline visit.
- Active cancer or cancer undergoing treatment
- Participation in other drug studies or the use of other investigational drugs within
30 days before screening.
- Known hypersensitivity to Coenzyme Q10.
- Pregnant, planning a pregnancy or nursing woman
We found this trial at
3
sites
Beth Israel Deaconess Medical Center Beth Israel Deaconess Medical Center (BIDMC) is one of the...
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Lahey Clinic When Frank Lahey, MD, founded a group practice in 1923, his vision was...
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