Randomized Control Trial Comparing Prokinetics and Their Influence on Endoscopy Outcomes for Upper GI Bleed.



Status:Completed
Conditions:Gastrointestinal
Therapuetic Areas:Gastroenterology
Healthy:No
Age Range:18 - 80
Updated:4/2/2016
Start Date:June 2014
End Date:December 2015

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Trial Summary
Trial Overview
Inclusion Criteria

This is a study comparing the effect of erythromycin or metoclopramide, 2 prokinetic drugs
(Drugs which are known to speed up the emptying of the stomach or in other words to move the
blood out of the stomach faster) given before endoscopy to patients with upper
Gastrointestinal bleeding compared to patients who will not receive either of these
medications before their endoscopy.

To compare the efficacy of pre-endoscopic interventions namely erythromycin, metoclopromide
vs control in improving the outcomes of endoscopy in ICU patients admitted upper GI
bleeding.

Specific aims:

1. Wither erythromycin, metoclopromide vs control can enable visualization of the entire
gastric mucosa .

2. Wither erythromycin, metoclopromide vs control can improve the quality of stomach and
duodenum visualization: using the scoring system by Fossard et al

Inclusion Criteria:

- Adult patients (18-80)

- who are admitted to the ICU for hematemesis, or coffee ground emesis

Exclusion Criteria:

1. Patients younger than 18 yrs old or older than 80 yrs

2. Patients who refuse to consent to be in our study

3. Pregnant patients

4. Prior use of prokinetics in the last 48 hours

5. History of cardiac arrhythmia

6. Allergy to erythromycin or metoclopromide

7. Patients with QT prolongation (query 7)
We found this trial at
1
site
Texas tech university health science center
415 East Yandell Drive
El Paso, Texas 79905
?
mi
from
El Paso, TX
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