Actinic Keratosis Study
| Status: | Completed |
|---|---|
| Conditions: | Dermatology |
| Therapuetic Areas: | Dermatology / Plastic Surgery |
| Healthy: | No |
| Age Range: | 50 - Any |
| Updated: | 5/20/2016 |
| Start Date: | October 2013 |
| End Date: | March 2015 |
The Role of Calcipotriol in Treatment of Pre-cancerous Skin Lesions
The main purpose of this study is to determine the effectiveness of a new combination
therapy for actinic keratosis. This study investigates a new indication for an FDA-approved
topical medication, calcipotriol, for treatment of actinic keratosis, including how well it
works and how safe it is when used in combination with the standard of care medication
(5-fluorouracil) for the skin condition.
therapy for actinic keratosis. This study investigates a new indication for an FDA-approved
topical medication, calcipotriol, for treatment of actinic keratosis, including how well it
works and how safe it is when used in combination with the standard of care medication
(5-fluorouracil) for the skin condition.
Inclusion Criteria:
- Age of at least 50 years
- Presence of four to fifteen clinically typical, visible, and discrete actinic
keratoses in 25 cm2 on any of the four anatomical sites: scalp, face, right upper
extremity and left upper extremity
- Ability and willingness of the patient to participate in the study (Informed consent
is obtained)
Exclusion Criteria:
- Treatment area is within 5 cm of an incompletely healed wound or a suspected
basal-cell or squamous-cell carcinoma
- Treatment area contained hypertrophic and hyperkeratotic lesions, cutaneous horns, or
lesions that had not responded to repeated cryotherapy
- Recent (within a month) use of medications that could interfere with evaluation of
the treatment area (e.g., topical medications, artificial tanners, immunosuppressive
medications, immunomodulating agents, cytotoxic drugs, ultraviolet B phototherapy,
other therapies for actinic keratoses, or oral retinoids)
- Premenopausal Women (to avoid any risk of pregnancy)
- History of hypercalcemia or clinical evidence of vitamin D toxicity
We found this trial at
1
site
660 S Euclid Ave
Saint Louis, Missouri 63110
Saint Louis, Missouri 63110
(314) 362-5000
Washington University School of Medicine Washington University Physicians is the clinical practice of the School...
Click here to add this to my saved trials
