TD-6450 SAD and MAD in Healthy Subjects

Inclusion Criteria:

- Subject is a female of non-childbearing potential or male, who is healthy,
nonsmoking, and 18 to 60 years old, inclusive, at screening. Females are considered
to be of non childbearing potential if they have had a hysterectomy or tubal ligation
(documentation required) or are postmenopausal (amenorrheic for at least 2 years)
with a follicle stimulating hormone (FSH) level >40 IU/L

- Subject has a body mass index 18 to 30 kg/m2, inclusive, and weighs at least 50 kg.

Exclusion Criteria:

- Subject has evidence or history of clinically significant allergic (except for
untreated, asymptomatic, seasonal allergies at time of dosing), hematological,
endocrine, pulmonary, gastrointestinal, cardiovascular, hepatic, psychiatric, or
neurological disease.

- Subject has an estimated creatinine clearance of <90 mL/min at Screening or Day -1,
calculated using the Cockcroft-Gault equation.

- Subject has participated in another clinical trial of an investigational drug (or
medical device) within 60 days prior to Screening, or is currently participating in
another trial of an investigational drug (or medical device).