Evaluation of Predictors of Aortic Aneurysm Growth and Rupture
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Cardiology, Cardiology, Cardiology |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | 21 - Any |
| Updated: | 1/11/2019 |
| Start Date: | May 2012 |
| End Date: | July 2020 |
Aortic Wall Behavior as a Predictor of Aortic Aneurysm Growth and Rupture
The goal is to non-invasively study the metabolic processes within the aortic wall that are
thought to explain progression to clinical manifestations of an aortic aneurysm.
Hypothesis is that the non-invasive imaging of Abdominal Aortic Aneurysm (AAA) with contrast
ultrasound, coupled with serum biomarker measurements will allow the identification of the
vulnerable aortic wall and patients who are at risk of AAA growth or rupture.
thought to explain progression to clinical manifestations of an aortic aneurysm.
Hypothesis is that the non-invasive imaging of Abdominal Aortic Aneurysm (AAA) with contrast
ultrasound, coupled with serum biomarker measurements will allow the identification of the
vulnerable aortic wall and patients who are at risk of AAA growth or rupture.
Aim#1: Prospective Contrast Ultrasound (CUS) imaging of patients with AAA to predict AAA
growth and test gender differences in rate of growth and rupture.
Aim#2: Serum biomarker testing of patient with AAA. CUS findings will be correlated with
serum biomarkers and AAA wall histology.
Prospective Contrast Ultrasound imaging of patients with AAA as part of a pilot feasibility
study to predict AAA growth and test gender differences in rate of growth and rupture. CUS
findings will be correlated with serum biomarkers and AAA wall histology. Potential
significance: This study will evaluate the AAA wall and will be based on detecting areas of
increased vasa vasorum density within the aneurysm wall and intraluminal thrombus, which
indicate regional ischemia and inflammation of the aortic wall and propensity for weakening,
enlargement or rupture. This novel evaluation of the aortic wall in patients with AAA will
allow individualized treatment based on the biological potential for growth and rupture.
growth and test gender differences in rate of growth and rupture.
Aim#2: Serum biomarker testing of patient with AAA. CUS findings will be correlated with
serum biomarkers and AAA wall histology.
Prospective Contrast Ultrasound imaging of patients with AAA as part of a pilot feasibility
study to predict AAA growth and test gender differences in rate of growth and rupture. CUS
findings will be correlated with serum biomarkers and AAA wall histology. Potential
significance: This study will evaluate the AAA wall and will be based on detecting areas of
increased vasa vasorum density within the aneurysm wall and intraluminal thrombus, which
indicate regional ischemia and inflammation of the aortic wall and propensity for weakening,
enlargement or rupture. This novel evaluation of the aortic wall in patients with AAA will
allow individualized treatment based on the biological potential for growth and rupture.
Inclusion Criteria:
- Diagnosis of AAA with confirmation of diagnosis of any size aneurysm with imaging.
- 21 years of age or older
- ability to give informed consent.
Exclusion Criteria:
- Inability to provide an informed consent
- Known allergy to Definity
- Unstable cardiopulmonary conditions
- pregnancy
We found this trial at
1
site
Pittsburgh, Pennsylvania 15232
Principal Investigator: Rabih Chaer, MD
Phone: 412-623-8486
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