Study of Dalantercept and Sorafenib in Patients With Advanced Hepatocellular Carcinoma

Inclusion Criteria:

- Histologically confirmed, locally advanced or metastatic HCC.

- Child-Pugh Score A (5-6)

- At least one target lesion that has not been treated with local therapy and is
measurable by Response Evaluation Criteria in Solid Tumors (RECIST) v1.1

- Eastern Cooperative Oncology Group (ECOG) performance status of 0-1.

- Life expectancy of at least 12 weeks.

- Able to tolerate oral therapy.

- Appropriate clinical laboratory values within 72 hours prior to study day 1:

- Females of child bearing potential (defined as sexually mature women who have not
undergone hysterectomy or bilateral oophorectomy, or are not naturally postmenopausal
≥ 24 consecutive months) must have negative urine or blood pregnancy test prior to
enrollment and use adequate birth control methods (abstinence, oral contraceptives,
barrier method with spermicide, or surgical sterilization) during study participation.
Males must agree to use a latex condom during any sexual contact with females of child
bearing potential while participating in the study and for 12 weeks following the last
dose of dalantercept, even if he has undergone a successful vasectomy. Patients must
be counseled concerning measures to be used to prevent pregnancy and potential
toxicities prior to the first dose of dalantercept.

Exclusion Criteria:

- Mixed tumor histology

- Prior systemic therapy for metastatic disease.

- Adjuvant therapy < 6 months prior to study day 1.

- Prior treatment with dalantercept or other agent targeting the ALK1 pathway.

- Prior treatment with sorafenib or other RAF/VEGF targeted therapies.

- Hepatic radiation, chemoembolization, and radiofrequency ablation < 4 weeks prior to
study day 1.

- Palliative radiation therapy to metastatic sites of disease < 2 weeks prior to study
day 1.

- Interferon therapy < 4 weeks prior to study day 1.

- Uncontrolled Hepatitis B despite appropriate therapy.

- Clinically significant pulmonary, endocrine, neurologic, hematologic, gastrointestinal
(GI), autoimmune, psychiatric or genitourinary disease unrelated to HCC that in the
judgment of the investigator should preclude treatment with dalantercept or sorafenib.

- Known HIV infection.

- Clinically significant cardiovascular risk

- Clinically significant active pulmonary risk

- Known active gastrointestinal (GI) bleeding.

- Known bleeding diathesis Known history of hereditary hemorrhagic telangiectasia (HHT).

- History of another primary cancer, with the exception of:

1. Curatively resected non melanoma skin cancer.

2. Curatively treated cervical carcinoma in situ.

3. Other primary solid tumor with no known active disease in the opinion of the
investigator that will not affect patient outcome in the setting of current HCC
diagnosis.

- Major surgery within 4 weeks prior to study day 1 Active infection Anti-coagulation
therapy Concomitant treatment with potent CYP3A4 inducers

- Peripheral edema ≥ grade 2 within 2 weeks prior to study day 1.

- History of recurrent ascites requiring paracentesis within 4 weeks of study day 1.

- History of severe (using the National Cancer Institute Common Toxicity Criteria for
Adverse Events, version 4.0 [NCI-CTCAE] v4 current minor version ≥ grade 3) allergic
or anaphylactic reaction or hypersensitivity to recombinant proteins or excipients