Idalopirdine in Patients With Mild-moderate Alzheimer's Disease Treated With Donepezil



Status:Completed
Conditions:Alzheimer Disease
Therapuetic Areas:Neurology
Healthy:No
Age Range:50 - Any
Updated:2/22/2018
Start Date:February 2014
End Date:December 2016

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Randomised, Double-blind, Parallel-group, Placebo-controlled, Fixed-dose Study of Idalopirdine in Patients With Mild-moderate Alzheimer's Disease Treated With Donepezil

To establish efficacy of Idalopirdine as adjunctive therapy to donepezil for symptomatic
treatment of patients with mild-to-moderate Alzheimer's disease (AD).

The study consisted of a screening period (up to 2-week period from screening to
randomization), a 24-week double-blind treatment period with placebo or idalopirdine 10
mg/day or 30 mg/day as adjunctive therapy to donepezil 10 mg/day, and a 4-week safety
follow-up period following study completion or withdrawal from treatment.

Inclusion Criteria:

- The patient has a knowledgeable and reliable caregiver.

- The patient is an outpatient.

- The patient has probable AD.

- The patient has mild to moderate AD.

- Stable treatment with donepezil.

- The patient, if a woman, must have had her last natural menstruation ≥24 months prior
to baseline, OR be surgically sterile.

- The patient, if a man, agrees to protocol-defined use of effective contraception if
his female partner is of childbearing potential, OR must have been surgically
sterilised prior to the screening visit.

Exclusion Criteria:

- The patient has evidence of any clinically significant neurodegenerative disease, or
other serious neurological disorders other than AD.

- The patient has a Diagnostic and Statistical Manual of Mental Disorders, 4th edition,
Text Revision (DSM-IV-TR) Axis I disorder other than AD.

- The patient has evidence of clinically significant disease.

- The patient's donepezil therapy is likely to be interrupted or discontinued during the
study.

- The patient is currently receiving memantine or has taken memantine within 2 months
prior to screening.

Other inclusion and exclusion criteria may apply.
We found this trial at
49
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Oceanside, California 92056
1949
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Oceanside, CA
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Allentown, Pennsylvania 18104
399
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Allentown, PA
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Anaheim, California 92804
1960
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Anaheim, CA
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Atlanta, Georgia 30308
434
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Atlanta, GA
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Augusta, Georgia
452
mi
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Augusta, GA
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Banfield,
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Banfield,
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Belmont, Massachusetts 02478
637
mi
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Belmont, MA
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344 Massachusetts Avenue
Boston, Massachusetts 02118
641
mi
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Boston, MA
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Carson, California 90746
1980
mi
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Carson, CA
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Charlotte, North Carolina 28211
348
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Charlotte, NC
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Cincinnati, Ohio 45219
94
mi
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Cincinnati, OH
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349 Ohio 3
Cleveland, Ohio 44195
126
mi
from 43215
Cleveland, OH
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306 South Ohio Avenue
Columbus, Ohio 43205
2
mi
from 43215
Columbus, OH
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Cordova, Tennessee
496
mi
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Cordova, TN
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Costa Mesa, California 92626
1963
mi
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Costa Mesa, CA
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Creve Coeur, Missouri 63141
405
mi
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Creve Coeur, MO
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Decatur, Georgia 30033
433
mi
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Decatur, GA
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Delray Beach, Florida 33445
947
mi
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Delray Beach, FL
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Fayetteville, Arkansas
662
mi
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Fayetteville, AR
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Fort Worth, Texas 76107
938
mi
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Fort Worth, TX
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Fullerton, California 92835
1957
mi
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Fullerton, CA
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Hallandale Beach, Florida 33009
980
mi
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Hallandale Beach, FL
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321 Mississippi Avenue
Hattiesburg, Mississippi 39401
693
mi
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Hattiesburg, MS
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347 Hialeah Drive
Hialeah, Florida 33016
989
mi
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Hialeah, FL
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12300 North Freeway
Houston, Texas 77060
983
mi
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Houston, TX
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334 Lakeshore Drive
Lake Charles, Louisiana 70629
884
mi
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Lake Charles, LA
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340 Lake Avenue
Lake Worth, Florida 33449
937
mi
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Lake Worth, FL
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352 West Ohio Place
Lakewood, Ohio 80226
1167
mi
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Lakewood, OH
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Lomita, California 90717
1982
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Lomita, CA
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339 Manchester Boulevard
Manchester, New Jersey 08759
457
mi
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Manchester, NJ
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Miami, Florida 33186
998
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Miami, FL
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Miami, Florida 33137
993
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Miami, FL
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Naples, Florida 34102
958
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Naples, FL
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337 Connecticut Avenue
New London, Connecticut 06320
579
mi
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New London, CT
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333 North Oklahoma Avenue
Oklahoma City, Oklahoma 73116
849
mi
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Oklahoma City, OK
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345 Florida Avenue
Orange City, Florida 32763
765
mi
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Orange City, FL
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Palm Beach Gardens, Florida 33418
922
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Palm Beach Gardens, FL
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Phoenix, Arizona 85013
1661
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Phoenix, AZ
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Pittsburgh, Pennsylvania 15260
165
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Pittsburgh, PA
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341 Penn Circle
Pittsburgh, Pennsylvania 15206
166
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Port Royal, South Carolina 29935
539
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Port Royal, SC
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Reading, Pennsylvania 19605
375
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Reading, PA
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Redlands, California 92374
1916
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Redlands, CA
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800 South Washington Avenue
Saint Paul, Minnesota 55401
625
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Saint Paul, MN
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Santa Rosa, California 95405
2083
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Santa Rosa, CA
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Stamford, Connecticut
503
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Stamford, CT
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Staten Island, New York 10312
469
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Staten Island, NY
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Sunrise, Florida 33019
977
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Sunrise, FL
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Winston-Salem, North Carolina
306
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Winston-Salem, NC
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