RNA Extraction and Amplification From Biopsy Specimens in Subjects With Metastatic Renal Cell Carcinoma (AGS-NTS-017)

Inclusion Criteria:

A subject with metastatic RCC, who in the opinion of the treating physician, is a potential
candidate for inclusion in this study if all of the following criteria apply:

1. 18 years of age or older.

2. Suspected RCC, in the opinion of the investigator

3. Availability of either:

- Nephrectomy or other surgically removed tissue (Stage I); or,

- Metastatic RCC biopsy tissue utilizing needle or core biopsy procedures (Stage
II).

4. ≥5 biopsy specimens available from BRPC.

- Subjects who are having a surgical procedure (i.e. metastasectomy, nephrectomy)
will have these core biopsies obtained from the surgical specimen, per the BRPC
protocol.

5. Not currently being treated with systemic therapy.

Exclusion Criteria:

1. Tumor tissue is committed to other use or inadequate for RNA analysis.

2. Insufficient tissue is collected in the BRPC.

Expansion Cohort for Genitourinary Cancers:

Inclusion Criteria:

1. 18 years of age or older

2. Suspected bladder, prostate, or testicular cancer, in the opinion of the investigator.

3. Availability of surgically removed tissue or biopsy tissue.

4. At least 2 biopsy specimens available from BRPC

5. Not currently being treated with systemic therapy.

Exclusion Criteria:

1. Tumor tissue is committed to other use or inadequate for RNA analysis.

2. Insufficient tissue is collected in the BRPC.