Study to Evaluate the Effect of GSK1265744 on Cardiac Conduction

Inclusion Criteria:

- Male and females aged between 18 and 55 years of age inclusive, at the time of
signing the informed consent.

- Healthy as determined by a responsible and experienced physician, based on a medical
evaluation including medical history, physical examination, laboratory tests and
cardiac monitoring.

- Body weight >=50 kilograms (kg) for men and >= 45 kg for women and body mass index
(BMI) within the range 18.5-31.0 kg/meter^2 (inclusive).

- A female subject is eligible to participate if she is of: non-childbearing potential
defined as pre-menopausal females with a documented tubal ligation, bilateral
oophorectomy or hysterectomy [for this definition, "documented" refers to the outcome
of the investigator's/designee's review of the subject's medical history for study
eligibility, as obtained via a verbal interview with the subject or from the
subject's medical records]; or postmenopausal defined as 12 months of spontaneous
amenorrhea [in questionable cases a blood sample with simultaneous follicle
stimulating hormone (FSH) > 40 milli international unit (MlU)/mililiter (m) and
estradiol < 40 picogram/mL (<147 picomoles/L) is confirmatory] OR has only same-sex
partners, when this is her preferred and usual lifestyle.

- Male subjects with female partners of child-bearing potential must agree to use one
of the contraception methods. This criterion must be followed from the time of the
first dose of study medication until 21 days post-last dose.

- Capable of giving written informed consent, which includes compliance with the
requirements and restrictions listed in the consent form.

Exclusion Criteria

- Current or chronic history of liver disease, or known hepatic or biliary
abnormalities (with the exception of Gilbert's syndrome or asymptomatic gallstones).

- History of regular alcohol consumption within 6 months of the study defined as: an
average weekly intake of >14 drinks for males or >7 drinks for females. One drink is
equivalent to 12 grams of alcohol: 12 ounces (360 mL) of beer, 5 ounces (150 mL) of
wine or 1.5 ounces (45 mL) of 80 proof distilled spirits.

- History of sensitivity to heparin or heparin-induced thrombocytopenia.

- History of sensitivity to any of the study medications, or components thereof or a
history of drug or other allergy that, in the opinion of the investigator or
GlaxoSmithKline (GSK) Medical Monitor, contraindicates their participation.

- A positive pre-study Hepatitis B surface antigen or positive Hepatitis C antibody
result within 3 months of screening.

- Use of tobacco- or nicotine-containing products within 6 months prior to screening.

- A positive pre-study drug/alcohol screen.

- A positive test for human immuno virus antibody.

- Subjects with an alanine aminotransferase, alkaline phosphatase and bilirubin
>=1.5xupper limit of normal (ULN) (isolated bilirubin <1.5xULN is acceptable if
bilirubin is fractionated and direct bilirubin >35%).

- The subject's systolic blood pressure is outside the range of 90 to140 milimeter of
mercury (mmHg) or diastolic blood pressure is outside the range of 45 to 90mmHg or
heart rate is outside the range of 50 to 100 beats per minute (bpm) for female
subjects or 45 to 100 bpm for male subjects.

- Exclusion criteria for screening ECG (a single repeat is allowed for eligibility
determination): are: male subjects with Heart rate <45 and >100 bpm and female
subjects with heart rate <50 and >100 bpm, PR <120 and >220 milliseconds (msec), QRS
duration <70 and >120 msec, QTcB >450 msec.

Evidence of previous myocardial infarction (Does not include ST segment changes associated
with repolarization).

Any conduction abnormality (including but not specific to left or right complete bundle
branch block, atrioventricular block [2nd degree or higher], Wolf Parkinson White
syndrome).

Sinus Pauses > 3 seconds. Any significant arrhythmia which, in the opinion of the
principal investigator and GSK medical monitor, will interfere with the safety for the
individual subject.

Non-sustained or sustained ventricular tachycardia (>=3 consecutive ventricular ectopic
beats).

- Where participation in the study would result in donation of blood or blood products
in excess of 500mL within a 56 day period.

- The subject has participated in a clinical trial and has received an investigational
product within the following time period prior to the first dosing day in the current
study: 30 days, 5 half-lives or twice the duration of the biological effect of the
investigational product (whichever is longer).

- Exposure to more than four new chemical entities within 12 months prior to the first
dosing day.