Cocaine Opioid Oxytocin Option - Limited



Status:Completed
Conditions:Psychiatric
Therapuetic Areas:Psychiatry / Psychology
Healthy:No
Age Range:18 - Any
Updated:10/20/2018
Start Date:July 2014
End Date:December 2014

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Trial Summary
Trial Overview
Inclusion Criteria

Chronic Intranasal Oxytocin as an Adjunct to Methadone Maintenance Treatment in Patients With Co-occuring Opioid Use Disorder and Cocaine Use: A 2-week Pilot Study

This is a pilot feasibility study assessing the tolerability of chronic administration of
intranasal oxytocin to patients receiving methadone at an opioid replacement clinic who are
actively using cocaine.


Inclusion Criteria:

- Enrolled as a patient in the San Francisco General Hospital Opioid Treatment
Outpatient Program

- Stable dose of methadone for at least the past two weeks

- At least one routine urine toxicology screen positive for cocaine in the past month

Exclusion Criteria:

- Positive urine pregnancy test

- Use of illicit drugs in the past month (with the exception of cocaine or cannabis)

- Currently meets Diagnostic and Statistical Manual-5 (DSM-V) criteria for severe major
depressive disorder with suicidal thoughts or actions

- History of psychotic or moderate-severe alcohol use disorder as defined by DSM-V
criteria

- Severe neuropsychological disorder, brain trauma, epilepsy

- Sensitivity to preservatives (in particular E 216, E 218 and chlorobutanol
hemihydrate)

- Nasal obstruction, discharge, or bleeding

- Habitually drinks large volumes of water

- Taking testosterone, estrogen/progesterone supplement, or serotonin-1a receptor
agonists/antagonists
We found this trial at
1
site
San Francisco General Hospital Opiate Treatment Outpatient Program
San Francisco, California 94110
?
mi
from
San Francisco, CA
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