Observational Study of Insulin Resistance and Muscle Wasting After Burn Injury
| Status: | Withdrawn |
|---|---|
| Conditions: | Hospital, Endocrine |
| Therapuetic Areas: | Endocrinology, Other |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 3/9/2019 |
| Start Date: | May 2014 |
| End Date: | May 2018 |
Project 4: Molecular Mechanisms in Burn-induced Insulin Resistance in Humans
The purpose of this study is to examine important and significant problems, that of insulin
resistance and muscle wasting after burn injury.
resistance and muscle wasting after burn injury.
Burn injury induces insulin resistance and our investigators have previous shown the
importance of insulin receptor substrate 1 (IRS-1)-mediated pathways. This project will
establish the inhibitory effects of burn injury on IRS-1 mediated signaling in human skeletal
muscle of burn patients.
importance of insulin receptor substrate 1 (IRS-1)-mediated pathways. This project will
establish the inhibitory effects of burn injury on IRS-1 mediated signaling in human skeletal
muscle of burn patients.
Inclusion Criteria:
- Burn injury >=10% total body surface area involvement from any etiology that will
require surgical treatment
- Age 18 years or older
- Admitted to the Massachusetts General Hospital within 30 days of burn injury
- Patient or guardian who is capable of giving full informed consent
Exclusion Criteria:
- Decision not to treat due to severity of injury
- Presence of anoxic brain injury that is not expected to result in complete recovery
- Existence of co-morbid conditions of malignancy currently under treatment, medical
condition requiring glucocorticoid treatment, insulin dependent diabetes mellitus,
morbid obesity defined as body mass index >= 40
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