Intensive Statin Therapy Effect on Post-Operative Atrial Fibrillation (POAF)
| Status: | Recruiting |
|---|---|
| Conditions: | Atrial Fibrillation |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | 19 - Any |
| Updated: | 6/17/2016 |
| Start Date: | August 2013 |
| End Date: | June 2017 |
| Contact: | Caroline Nubel |
| Email: | carolinenubel@creighton.edu |
| Phone: | 402-280-4032 |
Intensive Statin Therapy Effect on Incidence of Post-Operative Atrial Fibrillation
This study will compare the effects of 20 mg of atorvastatin to 80 mg of atorvastatin for
the prevention of atrial fibrillation after cardiothoracic surgery. The study hypothesis is
that 80 mg of atorvastatin will be more effective at preventing atrial fibrillation compared
to 20 mg.
the prevention of atrial fibrillation after cardiothoracic surgery. The study hypothesis is
that 80 mg of atorvastatin will be more effective at preventing atrial fibrillation compared
to 20 mg.
This is a randomized, double-blind comparison of two doses of atorvastatin for prevention of
post-operative atrial fibrillation.
post-operative atrial fibrillation.
Inclusion Criteria:
- Age 19 or older
- Undergoing elective cardiothoracic surgery
Exclusion Criteria:
- Emergency cardiothoracic surgery
- History of permanent atrial fibrillation
- Acute coronary syndrome within 7 days
- Antiarrhythmic drug use in the past 3 months
- Receiving maximal tolerated dose of statin therapy
- Receiving fibrate therapy
- History of statin intolerance
- Significant liver impairment (aspartate aminotransferase/alanine
aminotransferase(AST/ALT)>2x ULN)
- Serum Creatinine > 3 mg/dl
- Pregnancy or breastfeeding
We found this trial at
1
site
2500 California Plaza
Omaha, Nebraska 68102
Omaha, Nebraska 68102
(402) 280-2700
Principal Investigator: Aiman Smer, MBBCh
Creighton University Creighton University, located in Omaha, Neb., offers a top-ranked education in the Jesuit...
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