Gender Disparity in Burn Injury Survival
| Status: | Recruiting |
|---|---|
| Conditions: | Obesity Weight Loss, Hospital, Hospital |
| Therapuetic Areas: | Endocrinology, Other |
| Healthy: | No |
| Age Range: | 18 - 65 |
| Updated: | 1/10/2019 |
| Start Date: | December 2013 |
| End Date: | December 2019 |
| Contact: | Sharmila Dissanaike, MD |
| Email: | sharmila.dissanaike@ttuhsc.edu |
| Phone: | 806-743-2460 |
Hypothesis 1: A quantifiable difference in inflammatory cytokines exist in women with burn
injury and this correlates with clinical markers of outcome
Hypothesis 2: The amount of adipose tissue contributes to the severity of cellular immune
response (CMI) dysregulation in response to burn injury
Skin-fold caliper measurements will be taken on consented patients (both male and female) to
determine body fat percentage. Serum samples will be obtained from these patients. The level
of inflammatory cytokines in the serum will be measured to determine if there is a link
between body fat percentage, pro-inflammatory cytokines and the ability of women to survive
burn injury.
injury and this correlates with clinical markers of outcome
Hypothesis 2: The amount of adipose tissue contributes to the severity of cellular immune
response (CMI) dysregulation in response to burn injury
Skin-fold caliper measurements will be taken on consented patients (both male and female) to
determine body fat percentage. Serum samples will be obtained from these patients. The level
of inflammatory cytokines in the serum will be measured to determine if there is a link
between body fat percentage, pro-inflammatory cytokines and the ability of women to survive
burn injury.
Consented patients admitted to University Medical Center with greater than 15% total body
surface area burns will participate in this study. A skin-fold caliper measurement will be
performed to determine body fat percentage. Serum samples will be obtained and assayed for
inflammatory cytokines to establish whether or not a link between obesity in women and
pro-inflammatory cytokines exists. If so, obesity may be a factor which contributes to the
gender disparity in burn wound survival.
surface area burns will participate in this study. A skin-fold caliper measurement will be
performed to determine body fat percentage. Serum samples will be obtained and assayed for
inflammatory cytokines to establish whether or not a link between obesity in women and
pro-inflammatory cytokines exists. If so, obesity may be a factor which contributes to the
gender disparity in burn wound survival.
Inclusion Criteria:
- Men and women ages 18 to 65 years
- Admitted to University Medical Center with greater than 15% total body surface area
burns
- Able to provide informed consent or has authorized representative to give informed
consent
Exclusion Criteria:
- Prisoners or pregnant women
- Individuals with injuries that preclude taking caliper measurements
We found this trial at
1
site
Lubbock, Texas 79430
Principal Investigator: Sharmila Dissanaike, MD
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