Next Generation Sequencing Screening for Embryonic Ploidy Status
| Status: | Completed |
|---|---|
| Conditions: | Women's Studies, Infertility |
| Therapuetic Areas: | Reproductive |
| Healthy: | No |
| Age Range: | 18 - 42 |
| Updated: | 3/18/2017 |
| Start Date: | December 2013 |
| End Date: | January 2017 |
Evaluation of the Efficacy of Next Generation Sequencing in Predicting Embryonic Karyotype and Subsequent Pregnancy Outcomes in in Vitro Fertilization Cycles (IVF)
To evaluate the benefits of using next generation sequencing to assess embryonic aneuploidy.
All viable blastocysts will be biopsied and cryopreserved for future transfer. After the
final embryo is cryopreserved, patients will be randomized to either the intervention group
or the control group. Patients and doctors are blinded to the randomization until study
completion. A Double Embryo Transfer (DET) will be performed with either screened or
unscreened embryos depending on randomization. A Single Embryo Transfer (SET) may occur in
cases where only one embryo is available for transfer.
All viable blastocysts will be biopsied and cryopreserved for future transfer. After the
final embryo is cryopreserved, patients will be randomized to either the intervention group
or the control group. Patients and doctors are blinded to the randomization until study
completion. A Double Embryo Transfer (DET) will be performed with either screened or
unscreened embryos depending on randomization. A Single Embryo Transfer (SET) may occur in
cases where only one embryo is available for transfer.
Inclusion Criteria:
- Patient undergoing IVF/CCS (no PGD banking)
- Patient meets ASRM guidelines for Double Embryo Transfer (DET)
- Donor Sperm OK
- AMH ≥ 1.2
- FSH ≤ 12
- BAFC ≥12
- Max 1 prior failed IVF cycle for patients 35-45 years old
- Patient <35 years old MUST have 1 prior failed IVF cycle
Exclusion Criteria:
- Chronic endometrial insufficiency
- Use of oocyte donor or gestational carriers
- Medical contraindications to Double Embryo Transfer (DET)
- Male Factor (<100,000 sperm or surgical sperm)
- Communicating hydrosalpinx (on HSG)
- Single gene disorders or sex selection
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