Non-Enhanced Magnetic Resonance Angiography With the t-SLIP Technique

The t-SLIP Investigational Study Sequences are designed to compare t-SLIP to standard MR
contrast enhanced imaging techniques to establish the diagnosic benefits of t-SLIP compared
to contrast enhanced MR techniques. The t-SLIP Investigational Study Sequences will be used
for vascular MRI Imaging including, but no limited to, MRA of the renal, mesenteric,
abdominal aortic, iliac and femoral arteries. We will be targeting all adult patients
undergoing standard body MRA examinations without anesthesia.

The time spatial labeling inversion pulse (t-SLIP) technique is used for non contrast
enhanced MR angiography imaging. It produces bright blood spin labeling images by using a
single acquisition with a combination of a spatially nonselective inversion pulse and a
spatially selective inversion pulse. The nonselective pulse inverts the magnetization of the
entire imaging area. The spatially selective pulse, applied upstream of the arteries of
interest, reverts those protons to full magnetization. A pre defined time delay between
tagging and imaging allows the tagged spins to reach the imaging region and suppresses
background tissue within the imaging region to some extent.

Inclusion Criteria:

- All patients that are considered candidates and scheduled for standard contrast
enhanced MRA can be included in the study.

Exclusion Criteria:

- Patients that can not undergo standard MRA