Digital Breast Tomosynthesis Guided Tomographic Optical Breast Imaging (TOBI)
| Status: | Recruiting |
|---|---|
| Conditions: | Breast Cancer, Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 40 - 75 |
| Updated: | 4/21/2016 |
| Start Date: | March 2014 |
| End Date: | January 2019 |
| Contact: | David Boas, PhD |
| Email: | dboas@nmr.mgh.harvard.edu |
| Phone: | 617-724-0130 |
Screening for breast cancer improves early detection of aggressive cancers and has been
shown to reduce breast cancer related mortality. Currently, mammography is the most
effective way of detecting early stage, non palpable breast cancers. However, mammography
only reveals the breast structure, and cannot say much about the breast physiological state.
We propose Tomographic Optical Breast Imaging (TOBI) as an inexpensive, patient friendly
technique that is non-invasive and does not use non-ionizing radiation. TOBI uses near
infrared light and by measuring how such light passes through the breast, images of blood
volume and hemoglobin oxygenation can be obtained. In this study, TOBI is combined with
digital breast tomosynthesis (DBT, a form of 3D mammography) and our hypothesis is that the
TOBI-DBT combined images can be used to diagnose breast cancer with significantly improved
sensitivity and specificity compared to DBT alone.
shown to reduce breast cancer related mortality. Currently, mammography is the most
effective way of detecting early stage, non palpable breast cancers. However, mammography
only reveals the breast structure, and cannot say much about the breast physiological state.
We propose Tomographic Optical Breast Imaging (TOBI) as an inexpensive, patient friendly
technique that is non-invasive and does not use non-ionizing radiation. TOBI uses near
infrared light and by measuring how such light passes through the breast, images of blood
volume and hemoglobin oxygenation can be obtained. In this study, TOBI is combined with
digital breast tomosynthesis (DBT, a form of 3D mammography) and our hypothesis is that the
TOBI-DBT combined images can be used to diagnose breast cancer with significantly improved
sensitivity and specificity compared to DBT alone.
Inclusion Criteria:
- Any adult female volunteers of any race or ethnic background, between the ages of 40
to 75, either
- scheduled for a clinically indicated diagnostic mammogram or percutaneous
biopsy.
- presenting for breast cancer treatment
Exclusion Criteria:
- Under 40 years old or over 75 years old
- Is pregnant or thinks she may become pregnant.
- Open wounds on breast
- Breast implants
- Any condition that impairs the ability to give informed consent
We found this trial at
1
site
185 Cambridge Street
Boston, Massachusetts 02114
Boston, Massachusetts 02114
617-724-5200
Principal Investigator: David A Boas, PhD
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