A Trial Comparing the Safety and Efficacy of Insulin Degludec and Insulin Glargine, Both With Insulin Aspart as Mealtime Insulin in Subjects With Type 1 Diabetes



Status:Completed
Conditions:Diabetes, Diabetes
Therapuetic Areas:Endocrinology
Healthy:No
Age Range:18 - Any
Updated:1/3/2019
Start Date:January 5, 2014
End Date:January 11, 2016

Use our guide to learn which trials are right for you!

A Randomised, Double Blind, Cross-over Trial Comparing the Safety and Efficacy of Insulin Degludec and Insulin Glargine, Both With Insulin Aspart as Mealtime Insulin in Subjects With Type 1 Diabetes (SWITCH 1)

This trial is conducted in Europe and the United States of America (USA). The aim of the
trial is to compare the safety and efficacy of insulin degludec (IDeg) and insulin glargine
(IGlar), both with insulin aspart (IAsp) as mealtime insulin in subjects with type 1
diabetes.


Inclusion Criteria: - Subjects fulfilling at least one of the below criteria: a)
Experienced at least one severe hypo episode within the last year (according to the ADA
(American Diabetes Association) definition, April 2013) b) Moderate chronic renal failure,
defined as glomerular filtration rate 30 - 59 mL/min/1.73 m^2 per CKD-Epi (chronic kidney
disease epidemiology collaboration) c) Hypoglycaemic symptom unawareness d) Diabetes
mellitus duration for more than 15 years e) Recent episode of hypoglycaemia (defined by
symptoms of hypoglycaemia and/or episode with low glucose measurement (below or equal to 70
mg/dL [below or equal to 3.9 mmol/L])) within the last 12 weeks prior to Visit 1
(screening) - Male or female, age at least 18 years at the time of signing informed consent
- Type 1 diabetes mellitus (diagnosed clinically) for at least 52 weeks prior to Visit 1 -
Current treatment with a basal-bolus regimen consisting of neutral protamine Hagedorn (NPH)
insulin OD (once daily) / BID (twice daily) or insulin detemir (IDet) OD / BID plus 2-4
daily injections of any rapid acting meal time insulin or CSII (with rapid acting insulin)
for at least 26 weeks prior to Visit 1 - HbA1c (glycosylated haemoglobin) below or equal to
10% by central laboratory analysis - BMI (body mass index) below or equal to 45 kg/m^2
Exclusion Criteria: - Treatment with IGlar or IDeg within the last 26 weeks prior to Visit
1 (short term use [less than or equal to 2 weeks] is allowed, but not within 4 weeks prior
to screening) - Use of any other anti-diabetic agent than those stated in the inclusion
criteria within the last 26 weeks prior to Visit 1
We found this trial at
85
sites
Richland, Washington 99352
1862
mi
from 43215
Richland, WA
Click here to add this to my saved trials
Albany, New York 12208
513
mi
from 43215
Albany, NY
Click here to add this to my saved trials
Amarillo, Texas 79106
1078
mi
from 43215
Amarillo, TX
Click here to add this to my saved trials
Anderson, Indiana 46011
144
mi
from 43215
Anderson, IN
Click here to add this to my saved trials
Arlington Heights, Illinois 60004
348
mi
from 43215
Arlington Heights, IL
Click here to add this to my saved trials
Asheville, North Carolina 28801
302
mi
from 43215
Asheville, NC
Click here to add this to my saved trials
Austin, Texas 78731
1065
mi
from 43215
Austin, TX
Click here to add this to my saved trials
?
mi
from 43215
Bialystok,
Click here to add this to my saved trials
Billings, Montana 59101
1344
mi
from 43215
Billings, MT
Click here to add this to my saved trials
Birmingham, Alabama 35215
481
mi
from 43215
Birmingham, AL
Click here to add this to my saved trials
Carrollton, Texas 75007
906
mi
from 43215
Carrollton, TX
Click here to add this to my saved trials
Chattanooga, Tennessee 37404
362
mi
from 43215
Chattanooga, TN
Click here to add this to my saved trials
Chesapeake, Virginia 23321
418
mi
from 43215
Chesapeake, VA
Click here to add this to my saved trials
Chicago, Illinois 60612
274
mi
from 43215
Chicago, IL
Click here to add this to my saved trials
Concord, California 94520
2081
mi
from 43215
Concord, CA
Click here to add this to my saved trials
Cooper City, Florida 33024
973
mi
from 43215
Cooper City, FL
Click here to add this to my saved trials
Council Bluffs, Iowa 51501
678
mi
from 43215
Council Bluffs, IA
Click here to add this to my saved trials
Crystal Lake, Illinois 60012
388
mi
from 43215
Crystal Lake, IL
Click here to add this to my saved trials
Dallas, Texas 75231
905
mi
from 43215
Dallas, TX
Click here to add this to my saved trials
Denver, Colorado 80220
1161
mi
from 43215
Denver, CO
Click here to add this to my saved trials
El Paso, Texas 79912
1424
mi
from 43215
El Paso, TX
Click here to add this to my saved trials
Escondido, California 92025
1936
mi
from 43215
Escondido, CA
Click here to add this to my saved trials
Federal Way, Washington 98003
2005
mi
from 43215
Federal Way, WA
Click here to add this to my saved trials
Fleming Island, Florida 32003
686
mi
from 43215
Fleming Island, FL
Click here to add this to my saved trials
Fort Lauderdale, Florida 33316
972
mi
from 43215
Fort Lauderdale, FL
Click here to add this to my saved trials
Fresno, California 93702
1988
mi
from 43215
Fresno, CA
Click here to add this to my saved trials
Goodyear, Arizona 85395
1677
mi
from 43215
Goodyear, AZ
Click here to add this to my saved trials
Greenville, North Carolina 27834
430
mi
from 43215
Greenville, NC
Click here to add this to my saved trials
Hamilton, New Jersey 08619
472
mi
from 43215
Hamilton, NJ
Click here to add this to my saved trials
Harrison, New York 10528
?
mi
from 43215
Harrison, NY
Click here to add this to my saved trials
Hazelwood, Missouri 63042
400
mi
from 43215
Hazelwood, MO
Click here to add this to my saved trials
Henderson, Nevada 89052
1755
mi
from 43215
Henderson, NV
Click here to add this to my saved trials
Hialeah, Florida 33012
987
mi
from 43215
Hialeah, FL
Click here to add this to my saved trials
Houston, Texas 77030
995
mi
from 43215
Houston, TX
Click here to add this to my saved trials
Idaho Falls, Idaho 83404
1506
mi
from 43215
Idaho Falls, ID
Click here to add this to my saved trials
Indianapolis, Indiana 46260
166
mi
from 43215
Indianapolis, IN
Click here to add this to my saved trials
Jacksonville, Florida 32207
672
mi
from 43215
Jacksonville, FL
Click here to add this to my saved trials
Jefferson City, Missouri 65109
498
mi
from 43215
Jefferson City, MO
Click here to add this to my saved trials
800 Scudders Mill Road
Jenkintown, Pennsylvania 19046
445
mi
from 43215
Jenkintown, PA
Click here to add this to my saved trials
Kansas City, Missouri 64106
617
mi
from 43215
Kansas City, MO
Click here to add this to my saved trials
1008
mi
from 43215
Katy, TX
Click here to add this to my saved trials
Kingsport, Tennessee 37660
237
mi
from 43215
Kingsport, TN
Click here to add this to my saved trials
La Jolla, California 92037
1954
mi
from 43215
La Jolla, CA
Click here to add this to my saved trials
Las Vegas, Nevada 89128
1762
mi
from 43215
Las Vegas, NV
Click here to add this to my saved trials
Lawrenceville, Georgia 30046
418
mi
from 43215
Lawrenceville, GA
Click here to add this to my saved trials
Lenexa, Kansas 66219
630
mi
from 43215
Lenexa, KS
Click here to add this to my saved trials
Lexington, Kentucky 40503
157
mi
from 43215
Lexington, KY
Click here to add this to my saved trials
Livonia, Michigan 48152
166
mi
from 43215
Livonia, MI
Click here to add this to my saved trials
Long Beach, California 90807
1974
mi
from 43215
Long Beach, CA
Click here to add this to my saved trials
Mesquite, Texas 75149
903
mi
from 43215
Mesquite, TX
Click here to add this to my saved trials
Miami, Florida 33136
992
mi
from 43215
Miami, FL
Click here to add this to my saved trials
Miami Springs, Florida 33166
989
mi
from 43215
Miami Springs, FL
Click here to add this to my saved trials
Milwaukee, Wisconsin 53209
329
mi
from 43215
Milwaukee, WI
Click here to add this to my saved trials
Mineola, New York 11501
496
mi
from 43215
Mineola, NY
Click here to add this to my saved trials
Morehead City, North Carolina 28557
500
mi
from 43215
Morehead City, NC
Click here to add this to my saved trials
Nashua, New Hampshire 03063
629
mi
from 43215
Nashua, NH
Click here to add this to my saved trials
New Port Richey, Florida 34652
809
mi
from 43215
New Port Richey, FL
Click here to add this to my saved trials
Norfolk, Virginia 23510
423
mi
from 43215
Norfolk, VA
Click here to add this to my saved trials
Oklahoma City, Oklahoma 73112
849
mi
from 43215
Oklahoma City, OK
Click here to add this to my saved trials
Omaha, Nebraska 68114
682
mi
from 43215
Omaha, NE
Click here to add this to my saved trials
Pembroke Pines, Florida 33026
978
mi
from 43215
Pembroke Pines, FL
Click here to add this to my saved trials
Philadelphia, Pennsylvania 19104
414
mi
from 43215
Philadelphia, PA
Click here to add this to my saved trials
Pittsburgh, Pennsylvania 15224
163
mi
from 43215
Pittsburgh, PA
Click here to add this to my saved trials
Port Charlotte, Florida 33952
899
mi
from 43215
Port Charlotte, FL
Click here to add this to my saved trials
Port Orange, Florida 32127
756
mi
from 43215
Port Orange, FL
Click here to add this to my saved trials
Raleigh, North Carolina 27610
375
mi
from 43215
Raleigh, NC
Click here to add this to my saved trials
Rancho Cucamonga, California 91730
1936
mi
from 43215
Rancho Cucamonga, CA
Click here to add this to my saved trials
Renton, Washington 98057
2001
mi
from 43215
Renton, WA
Click here to add this to my saved trials
Richardson, Texas 75080
900
mi
from 43215
Richardson, TX
Click here to add this to my saved trials
Salt Lake City, Utah 84132
1513
mi
from 43215
Salt Lake City, UT
Click here to add this to my saved trials
San Antonio, Texas 78224
1138
mi
from 43215
San Antonio, TX
Click here to add this to my saved trials
San Mateo, California 94401
2108
mi
from 43215
San Mateo, CA
Click here to add this to my saved trials
San Ramon, California 94583
2084
mi
from 43215
San Ramon, CA
Click here to add this to my saved trials
Santa Monica, California 90404
1984
mi
from 43215
Santa Monica, CA
Click here to add this to my saved trials
Schertz, Texas 78154
1122
mi
from 43215
Schertz, TX
Click here to add this to my saved trials
Skokie, Illinois 60077
285
mi
from 43215
Skokie, IL
Click here to add this to my saved trials
Spokane, Washington 99202
1776
mi
from 43215
Spokane, WA
Click here to add this to my saved trials
Sugar Land, Texas 77479
1009
mi
from 43215
Sugar Land, TX
Click here to add this to my saved trials
Syracuse, New York 13210
414
mi
from 43215
Syracuse, NY
Click here to add this to my saved trials
117
mi
from 43215
Toledo, OH
Click here to add this to my saved trials
Topeka, Kansas 66606
676
mi
from 43215
Topeka, KS
Click here to add this to my saved trials
Upland, California 91786
1940
mi
from 43215
Upland, CA
Click here to add this to my saved trials
Ventura, California 93003
2017
mi
from 43215
Ventura, CA
Click here to add this to my saved trials
Walla Walla, Washington 99362
1817
mi
from 43215
Walla Walla, WA
Click here to add this to my saved trials
West Des Moines, Iowa 50265
571
mi
from 43215
West Des Moines, IA
Click here to add this to my saved trials