Aerobic Training for Management of Post-Concussion Syndrome in Adolescents

Concussion or mild traumatic brain injury (mTBI) is a public health problem and it is
imperative that efficacious treatment protocols be developed to reduce the morbidity
associated with PCS in adolescents. In adolescent athletes, timely return of normal
neurocognitive function and return to sports safely is critical to normal development. The
proposed study will fill a critical gap by systematically evaluating the potential efficacy
of an aerobic training intervention for management of PCS in adolescents. To our knowledge,
this will be the first randomized controlled study to evaluate the efficacy of aerobic
training for treatment of PCS in adolescents as soon as four weeks after injury. The study
will also improve our understanding of the pathophysiology of PCS and the biologic influence
of aerobic training on PCS. The proposed study will fill a critical gap and inform the
development of larger studies to assess the efficacy, and if proven efficacious, optimize
the timing and intensity of aerobic training treatment protocols, thus transforming the care
and limiting the adverse public impact of this condition.

Inclusion Criteria:

- Adolescents ages 12 to 17 years

- Experienced a concussion 4 to 16 weeks prior to enrollment

- Experiencing persistent post-concussion symptoms

Exclusion Criteria:

- Sustained a moderate to severe head injury, head injury more severe than concussion
or required an overnight hospital stay

- Younger than 12 years of age when beginning the study.

- Older than 17 years of age when beginning the study.

- Do not live with a parent/guardian.

- Injured more than 16 weeks ago.

- Do not speak or read English.

- Diagnosed with a developmental disability.

- Neurological impairment, cognitive disorders, genetic disorders, metabolic disorders,
blood disorder, cardiovascular problem/disease, and/or cancer.

- Inpatient admission for a psychiatric disorder within the past 12 months.

- Taking beta-blockers, anti-depressants, and/or anti-epileptic medications that cannot
be discontinued while participating in the study.

- Cardiovascular condition that would preclude participation in the training protocol.

- Any condition that precludes magnetic resonance imaging (MRI).

- Females that are pregnant or become pregnant during the study.