High Resolution Magnetic Resonance Imaging in Patients With Brain Tumors

The study is designed to directly compare the MR images of a brain tumor obtained on the 3T
and then 7T MRI in approximately 150 patients followed serially with MR imaging to evaluate
for tumor progression.

Inclusion Criteria:

- Male or female, age 18 years or older

- Patient must meet at least one of the four following criteria regarding brain tumor
diagnosis:

- Histological diagnosis of a brain tumor

- Histological diagnosis of systemic cancer and brain MR imaging suggestive of
metastatic disease to the brain

- Pre-operative brain MR imaging suggestive of a brain tumor

- Radiographic diagnosis of brain tumor in an inoperable location (e.g., brainstem)

- Patient able and willing to provide informed consent

- Karnofsky Performance status > 70%

- Life expectancy greater than 3 months

- Negative serum or urine pregnancy test or child bearing potential terminated by
surgery, radiation, menopause or current use of two approved methods of birth control

- Patients who are excluded from 7T MR imaging because of titanium implants that are not
yet established to be safe at 7T remain eligible for the imaging at 3T * Spanish
speaking participants will be enrolled for this study

Exclusion Criteria:

- Body weight >137 Kg (300 lbs)

- Patient unable to provide informed consent

- Karnofsky Performance status < 70%

- Patients who are claustrophobic or have other contraindications to MRI, such as
implanted pacemaker device vascular clips, surgical clips, prosthetic valves,
pacemakers, otologic implants

- NYHA class III and IV congestive heart failure

- Psychiatric or addictive disorders that preclude obtaining informed consent

- Unstable angina

- Sexually active patients of childbearing potential not using a reliable contraceptive
method

- Pregnant or lactating women

- Women of childbearing potential who refuse a pregnancy test (performed during
screening)