Corticospinal Excitability and Rehab in Knee Osteoarthritis
| Status: | Completed |
|---|---|
| Conditions: | Arthritis, Osteoarthritis (OA) |
| Therapuetic Areas: | Rheumatology |
| Healthy: | No |
| Age Range: | 19 - 65 |
| Updated: | 4/21/2016 |
| Start Date: | November 2013 |
| End Date: | June 2015 |
To determine differences in thigh muscle function in individuals with and without knee
arthritis, and also determine the effectiveness of common physical therapy interventions on
clinical and patient oriented outcomes.
arthritis, and also determine the effectiveness of common physical therapy interventions on
clinical and patient oriented outcomes.
The primary objective of the proposed research evaluates the concurrent changes in
corticospinal excitability and central sensitization of pain pathways for their influence on
quadriceps voluntary activation. A secondary objective is to establish the feasibility of an
intervention study to determine if changes in the excitability of these supraspinal motor
and sensory processes can be modified by physical therapy interventions targeting pain and
muscle strengthening. We hypothesize that patients with knee osteoarthritis will show
measurable deficits in quadriceps voluntary activation that can be explained by lower levels
of corticospinal excitability and increased pain sensitization. A 1 week physical therapy
intervention will improve voluntary activation and reduce pain with concurrent changes in
underlying motor and sensory processes. We further hypothesize that part of this improvement
will be attributed to positive treatment expectation.
corticospinal excitability and central sensitization of pain pathways for their influence on
quadriceps voluntary activation. A secondary objective is to establish the feasibility of an
intervention study to determine if changes in the excitability of these supraspinal motor
and sensory processes can be modified by physical therapy interventions targeting pain and
muscle strengthening. We hypothesize that patients with knee osteoarthritis will show
measurable deficits in quadriceps voluntary activation that can be explained by lower levels
of corticospinal excitability and increased pain sensitization. A 1 week physical therapy
intervention will improve voluntary activation and reduce pain with concurrent changes in
underlying motor and sensory processes. We further hypothesize that part of this improvement
will be attributed to positive treatment expectation.
Inclusion Criteria:
- Age 19-65
- Grade I or II knee Osteoarthritis confirmed by radiographs or other imaging and at
least one of the following:
- Age > 50 years old
- Morning stiffness < 30 minutes
- Crepitus
- Meet at least 3 of 6 diagnostic criteria for osteoarthritis:
- Age > 50 years old
- Morning stiffness < 30 minutes
- Crepitus
- Bony tenderness
- Bony enlargement
- No palpable warmth
Exclusion Criteria:
- BMI > 30
- History of traumatic spine or lower extremity injury within the last 6 months
- Previous adverse reaction to electrical stimulation (i.e. burns or hypersensitivity)
- Cardiac pacemaker
- Metal implants in head
- Current pregnancy
- Neurological disorders
- History of seizures
- Unable to give consent or understand the procedures of this study
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Creighton University Creighton University, located in Omaha, Neb., offers a top-ranked education in the Jesuit...
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