A Study to Assess the Effect of a Single Infusion of VAY736 on Disease Activity in Patients With Relapsing-remitting Multiple Sclerosis

Inclusion Criteria:

18 Years to 55 Years Male and Female

- Diagnosis of MS as defined by the 2010 revised McDonald criteria (Polman, et. al2011).

- A relapsing-remitting course of disease with:

- at least 1 documented relapse during the previous 12 months (but not within 30
days prior to randomization), or

- a positive Gd-enhancing lesion on brain MRI scan at screening.

- An Expanded Disability Status Scale (EDSS) score of 0-5.0 inclusive at screening.

- No evidence of a relapse within 30 days prior to randomization.

Exclusion Criteria:

- • A manifestation of another type of MS other than RRMS.

- Findings on screening or baseline brain MRI inconsistent with the diagnosis of
MS.

- History of chronic disease of the immune system other than MS, or a known
immunodeficiency syndrome

- Women of child-bearing potential, defined as all women physiologically capable of
becoming pregnant, unless they are using highly effective methods of
contraception during dosing and for 4 months following completion of the study.

- Unable to undergo MRI scans due to inter-alia, claustrophobia, incompatible
cardiac pacemakers, ferromagnetic intracranial aneurysm clips, certain cochlear
implants, and certain other ferromagnetic foreign bodies (e.g. tattoos containing
metal) or electronic devices, or metallic implants incompatible with MRI.

- Unable to receive gadolinium-based MRI contrast agents due to a history of
hypersensitivity to gadolinium-based contrast agents, renal insufficiency or
impairment.

Other protocol-defined inclusion/exclusion criteria may apply