Ultrasonographic Measurements of the Median Nerve Before and After Splinting for Carpal Tunnel Syndrome

Inclusion Criteria:

- 18 years or older and;

- Diagnosis of mild to moderate CTS with median motor latency at 8 cm is greater than
4.5 milliseconds or Combined Sensory Index > 0.9 where first line therapy is
indicated to include nocturnal wrist bracing

- Control subjects without symptoms of carpal tunnel syndrome.

Exclusion Criteria:

- Evidence of severe CTS as seen with electromyographic changes in the body of the
muscle

- Untreated hypothyroidism, Rheumatologic disorders

- Diagnosed Severe CTS or Chronic symptoms of carpal tunnel, greater than 1 year, this
includes wasting of the hand muscles

- Undergoing or previously treated for carpal tunnel on affected side. This includes
surgery (carpal tunnel release), corticosteroid injections, bracing within the last 3
months while wearing the brace consistently every night, or any other intervention.

- Currently pregnant or < 3 months post partum

- History of wrist, hand fracture or severe trauma to affected hand and/or wrist

- Known tumor, mass or deformity of the hand/wrist

- Inflammatory articular disease of the joints or tendons Existing cervical
radiculopathy or previous surgeries to the neck for radicular symptoms

- History of electrodiagnostic evidence of generalized polyneuropathy or evidence of
denervation

- Diagnosed neuromuscular disorders which may complicate CTS diagnosis

- Implanted electronic device (pacemaker, intrathecal pump/stimulator)

- Any illness that makes it unsafe for the patient to participate in the study

- Not fluent in English as NeuroQOL and other subjective information is limited to the
English language interpretation