A Five-Treatment-Period Study to Evaluate the Single-Dose Pharmacokinetics and Pharmacodynamics of Avatrombopag in Healthy Japanese and White Subjects

The study will comprise a Prerandomization Phase and a Randomization Phase. The
Prerandomization Phase will include 2 periods, Screening and Baseline 1. The Screening
Period will be up to 3 weeks (21 days) in duration. The Randomization Phase will consist of
5 single-dose treatment periods, of which 3 will include administration of avatrombopag in
the fed condition and 2 will include administration of avatrombopag in the fasted condition.
Each treatment period will be separated by a wash out interval of at least 28 days. Before
each treatment period, subjects will complete a baseline period (Baseline Periods 2, 3, 4,
and 5), during which baseline assessments will be collected. A Final Visit will occur 28
days (+/- 1 day) after dosing in Treatment Period 5.

Inclusion Criteria

1. Platelet count between the lower limit of normal and 350 x 109/L, inclusive, at
Screening and each Baseline; measurements can repeated for verification, if necessary

2. Nonsmoking, healthy white and Japanese adult male and female subjects, greater than
or equal to 20 years and less than or equal to 55 years old at the time of informed
consent. (Nonsmokers are defined as those who have discontinued smoking for at least
4 weeks before dosing.)

3. Japanese subjects must be born in Japan of Japanese parents and Japanese
grandparents, must have lived no more than 5 years outside of Japan, and must not
have changed their lifestyle or habits, including diet, while living outside of
Japan.

4. Body mass index greater than or equal to 18 and less than or equal to 28 kg/m2 at
Screening and Baseline Period 1. The BMI in white subjects must be within +/- 2 kg/m2
of the BMI in Japanese subjects.

5. Nonsmoking, healthy white and Japanese adult males and females between the ages of
20 and 55, inclusive

6. BMI between 18 and 28. inclusive

7. Females must not be pregnant or lactating, and if they are of childbearing potential
they must agree to use a highly effective method of contraception or abstain

8. Males must have a vasectomy or they and their partner must use a highly effective
method of contraception

Exclusion Criteria

1. Evidence of organ dysfunction or any clinically significant deviation from normal in
their medical history (eg, history of splenectomy); history of arterial or venous
thrombosis, including partial or complete thromboses (eg, stroke, transient ischemic
attack, myocardial infarction, deep vein thrombosis, pulmonary embolism); known
family history of hereditary thrombophilic disorders (eg, Factor V Leiden,
antithrombin III deficiency)

2. Recent clinically significant illness or infection that requires medical treatment

3. Evidence of disease that may influence the outcome of the study (eg, psychiatric
disorders, disorders of the gastrointestinal tract, liver, kidney, respiratory
system, endocrine system, hematological system, neurological system, or
cardiovascular system), or subjects who have a congenital abnormality in metabolism

4. Any history of gastrointestinal surgery (eg, hepatectomy, nephrotomy, digestive organ
resection)

5. Any clinically abnormal symptom or organ impairment found by medical history,
physical examination, vital sign electrocardiogram (ECG) assessment, or laboratory
test results

6. A known or suspected history of drug or alcohol dependency or abuse or a positive
urine drug, cotinine, or alcohol test

7. Positive results for human immunodeficiency virus (HIV), hepatitis B surface antigen
(HBsAg), or hepatitis C virus (HCV) antibody at Screening

8. Weight loss or gain of >10% within 4 weeks before dosing

9. Known history of clinically significant drug or food allergy

10. Currently enrolled in another clinical trial