Pilot Study of Multi-Modality Imaging in Patients With Hematologic Malignancies

Inclusion Criteria:

- Diagnosis of hematologic malignancy and fitting into one of the following categories:

- Newly diagnosed and/or day 14 post-induction chemotherapy

- Relapsed, including relapse after hematopoietic cell transplant

- Planned hematopoietic cell transplant (if enrolling at "close") or within 100
days post hematopoietic cell transplant (if enrolling post-transplant) with a
preparative regimen that includes either total marrow irradiation (TMI) or total
body irradiation (TBI)

- Undergoing natural killer cell therapies (with or without subsequent transplant)

- Aged 18 years and older

- Not pregnant - women of childbearing potential will have a confirmatory pregnancy test
prior to each imaging per routine procedures

- Adequate renal function (estimated glomerular filtration rate > 60 ml/min) as
determined by a serum creatinine level performed as a part of standard of care within
7 days of imaging

- Able and willing to provide written consent

Exclusion Criteria:

- Otherwise eligible patients meeting one or more of the contraindicates for an MRI, may
enroll in the study without undergoing the MRI:

- ferromagnetic implants

- history of shrapnel or shot gun injury

- too large to fit in the magnet (approximate body mass index ≥ 40)

- cardiac pacemakers or other implanted devices that are not MR-compatible

- claustrophobia

- large tattoos