Identification of Phenotypic Factors That Predict Success for Weight Loss and Long-term Weight Maintenance
| Status: | Recruiting |
|---|---|
| Conditions: | Obesity Weight Loss |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | 18 - 63 |
| Updated: | 9/23/2018 |
| Start Date: | August 2009 |
| End Date: | December 2025 |
| Contact: | Amy E Rothberg, MD, PhD |
| Email: | arothber@med.umich.edu |
| Phone: | 734-647-5871 |
The Investigational Weight Management Clinic at the University of Michigan was created to
identify strategies that will result in cost-effective, long term weight management for
overweight and obese individuals. The driving hypothesis of the clinic is that the 'one size
fits all' philosophy is untenable with a complex disease such as obesity. The clinic will
serve as a portal for patients to choose standard clinical care or to explore alternatives
from a variety of clinical studies offered through the clinic. These studies will include
further investigations into nutrition, the biological basis of weight and weight management
and protocols using approved and experimental pharmaceuticals.
identify strategies that will result in cost-effective, long term weight management for
overweight and obese individuals. The driving hypothesis of the clinic is that the 'one size
fits all' philosophy is untenable with a complex disease such as obesity. The clinic will
serve as a portal for patients to choose standard clinical care or to explore alternatives
from a variety of clinical studies offered through the clinic. These studies will include
further investigations into nutrition, the biological basis of weight and weight management
and protocols using approved and experimental pharmaceuticals.
Inclusion Criteria:
- Obese males and females: age >20 years; Obese population defined as BMI > or = 27
kg/m2
- Lean population BMI < 27 but > 17 kg/m2
- Able and willing to provide written informed consent for the trial
Exclusion Criteria:
- Evidence of inherited disorders of lipid metabolism.
- History of Cancer within the last 5 years
- Human immunodeficiency virus (HIV) antibody positive.
- Patients with solid organ transplants.
- Participation in any other clinical trial within 90 days of entry into this trial.
- Pregnant or lactating females.
- Uncontrolled thyroid disease
- Unstable angina or NY heart association class II failure or above
- Gastrointestinal disease specifically GI motility disorders
- Unstable neuropsychiatric disease including major depression/anxiety, eating disorder
such as binge eating, bulimia or anorexia
- End stage renal or hepatic disease
- Autoimmune disorders (e.g. SLE)
- Body weight fluctuation of more than 5 kg in the previous 3 months
- Prior bariatric surgery
- A history or current alcohol/substance abuse and change in smoking habits or cessation
in the past 6 months.
- Women of childbearing age must use a reliable form of contraception.
- Any medical condition, which in the opinion of the investigator would make the patient
unsuitable for recruitment, or could interfere with the patient participating in or
completing the protocol.
- Unwilling or unable to consent for the study.
We found this trial at
1
site
500 S State St
Ann Arbor, Michigan 48109
Ann Arbor, Michigan 48109
(734) 764-1817
Principal Investigator: Amy E Rothberg, MD, PhD
Phone: 734-647-5871
University of Michigan The University of Michigan was founded in 1817 as one of the...
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