Optimization of MRI for Radiation Therapy
| Status: | Recruiting |
|---|---|
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 10/28/2017 |
| Start Date: | February 2013 |
| End Date: | October 2021 |
| Contact: | Shruti Jolly, MD |
| Email: | shrutij@umich.edu |
| Phone: | 734-936-4300 |
Currently, appropriate patients undergo MRI imaging with immobilization and sequences
optimized for diagnostic radiology purposes. Using a mutual information algorithm, these
images are then registered to a treatment planning CT obtained with custom immobilization to
minimize intra-and inter-treatment motion and positional variation. This image registration
process is time-consuming and introduces additional layers of geometric uncertainty into what
should be a highly precise treatment planning process. However, it is necessary, since
radiation dose calculations cannot be performed on MRI data due to the lack of crucial
density information. The investigator envisions CT-less treatment planning, using only MRI,
due to superior imaging characteristics, fully integrated into the radiation oncology clinic.
This study will begin this process.
optimized for diagnostic radiology purposes. Using a mutual information algorithm, these
images are then registered to a treatment planning CT obtained with custom immobilization to
minimize intra-and inter-treatment motion and positional variation. This image registration
process is time-consuming and introduces additional layers of geometric uncertainty into what
should be a highly precise treatment planning process. However, it is necessary, since
radiation dose calculations cannot be performed on MRI data due to the lack of crucial
density information. The investigator envisions CT-less treatment planning, using only MRI,
due to superior imaging characteristics, fully integrated into the radiation oncology clinic.
This study will begin this process.
Inclusion Criteria:
- Patients ≥18 years of age
- A working diagnosis of malignancy in the liver, brain, H&N, or pelvis
- A plan to treat with radiotherapy
Exclusion Criteria:
- Patients with contraindications to having a contrast enhanced MRI scan. These
contraindications will be assessed at the time of enrollment using the guidelines set
up and in clinical use by the Radiology Department.
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