Using the Canary Breathing System for Panic Disorder Patients

Panic disorder (PD) is associated with hyperventilation. The efficacy of a brief respiratory
feedback program for PD has been previously established. The aim of the present study was to
expand these results by testing a similar program with more clinically representative
patients and settings. The intervention is delivered via home use following initial training
by a clinician and provides remote monitoring of client adherence and progress by the
clinician. Outcomes were assessed post-treatment and at 2- and 12-month follow-up.

Inclusion Criteria:

- Primary diagnosis of Panic Disorder

- Subjects between 18 and 60 years of age (inclusive on day of enrollment)

- Subjects with a Clinician's Global Impression of > or = to 4.

- If on psychotropic medication, on a stable dose for a minimum of 3 months prior to
enrollment

- If on psychotropic medication, an agreement to stay on their stable dose from study
entry until the 2-month follow-up.

Exclusion Criteria:

- Pregnancy

- Current enrollment in another drug or device study

- Current enrollment in another drug or device study that is not at least 30 days past
the final follow-up

- Currently undergoing cognitive behavioral therapy (or equivalent)

- Refractory to either a breathing training program or cognitive behavioral therapy (or
equivalent) in the 3 months prior to enrollment

- Evidence of organic mental disorder

- Severe suicidality

- Presence of any psychotic disorder

- Bipolar disorder that is present for < 5 years; a major depressive, manic or hypomanic
episode in the last 12 months; failure to take and maintain a stable dose of
medication in treatment of bipolar disorder in the last 12 months

- Current alcohol or drug dependence

- Cardiovascular or pulmonary disease

- Epilepsy or seizures

- Undergoing additional psychologic treatment at any point from study enrollment to
2-month follow-up to treat panic disorder