To Evaluate Pharmacokinetics of LFF269 in Healthy Volunteers and Patients With Hypertension

Inclusion Criteria:

Part 1

- Healthy men and women of non-childbearing potential, 18 to 80 years of age inclusive,
and in good health as determined by past medical history, physical examination, vital
signs, electrocardiogram, and laboratory tests at screening.

Part 2

- Hypertensive men and women of non-childbearing potential, 18 to 80 years of age
inclusive.

- Patients with mild-to-moderate uncomplicated essential hypertension

Exclusion Criteria:

Part 1

- History of hypersensitivity or allergy to any of the study drugs or to drugs of
similar chemical classes.

- A history of clinically significant ECG abnormalities.

- Known history or current clinically significant arrhythmias.

- History of hypertension, adrenal or endocrine disease.

- Pregnant or nursing (lactating) women, where pregnancy is defined as the state of a
female after conception and until the termination of gestation, confirmed by a
positive hCG laboratory test.

- Women of child-bearing potential, defined as all women physiologically capable of
becoming pregnant.

- Smokers (use of tobacco products in the previous 3 months).

- History of immunodeficiency diseases, including a positive HIV (ELISA and Western
blot) test result.

- A positive Hepatitis B surface antigen or Hepatitis C test result.

Part 2

- Pregnant or nursing (lactating) women.

- Women of child-bearing potential.

- Known history or evidence of a secondary form of hypertension

- Type 1 or type 2 diabetes mellitus.

- History of heart diseases

- A positive Hepatitis B surface antigen (HBsAg) or Hepatitis C test result.

- History of immunodeficiency diseases, including a positive HIV (ELISA and Western
blot) test result.

Other protocol defined inclusion/exclusion criteria may apply