The Effects of Exercise on Appetite Regulation in Overweight/Obese Individuals
| Status: | Recruiting |
|---|---|
| Conditions: | Obesity Weight Loss, Obesity Weight Loss |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | 21 - 45 |
| Updated: | 2/1/2019 |
| Start Date: | February 2014 |
| End Date: | December 2019 |
| Contact: | Marc-Andre Cornier, MD |
| Email: | marc.cornier@ucdenver.edu |
| Phone: | 303-724-0890 |
In this study the Investigators are examining the effects of a 12-week exercise program
(intervention) on measures of appetite and food intake regulation in overweight to mildly
obese healthy adults. The Investigators hypothesize that individuals who lose a significant
amount of weight in response to the intervention will show a reduction in the brain response
to food cues as measured by functional magnetic resonance imaging (fMRI) when compared to
those who do not lose weight. These changes in neuronal activity will be associated to
physiologic and behavioral measures.
(intervention) on measures of appetite and food intake regulation in overweight to mildly
obese healthy adults. The Investigators hypothesize that individuals who lose a significant
amount of weight in response to the intervention will show a reduction in the brain response
to food cues as measured by functional magnetic resonance imaging (fMRI) when compared to
those who do not lose weight. These changes in neuronal activity will be associated to
physiologic and behavioral measures.
Inclusion Criteria:
- all ethnic groups and both genders;
- age: 21-45 yrs;
- BMI: 27-35;
- weight stable within +/- 5 percent in the last 6 months;
- sedentary (less than 1 hour of planned physical activity by self-report).
Exclusion Criteria:
- history of cardiovascular disease (CVD), diabetes mellitus, uncontrolled hypertension,
untreated thyroid disease, renal disease, hepatic disease, or any other medical
condition affecting weight or energy metabolism;
- unable to effectively exercise due to cardiac, pulmonary, neurologic or orthopedic
reasons;
- unable to pass screening graded exercise treadmill test;
- currently smoking;
- medications affecting weight, Energy Intake (EI) or Energy Expenditure (EE) in the
last 6 months;
- weight loss or weight gain of >5 percent in past 6 months;
- currently pregnant, lactating or less than 6 months post-partum;
- bariatric surgery;
- major psychiatric disorder, presence of alcohol or substance abuse, current depression
by history and/or a score >21 on the he Center for Epidemiologic Studies Depression
Scale (CES-D), history of eating disorders and/or a score of >20 on the EATS-26;
- contraindication to MRI
We found this trial at
1
site
Aurora, Colorado 80045
Principal Investigator: Marc-Andre Cornier, MD
Phone: 303-724-0890
Click here to add this to my saved trials
