An Open-label Extension Study Evaluating the Safety and Efficacy of Upadacitinib (ABT-494) in Rheumatoid Arthritis Subjects

Inclusion Criteria:

1. Subjects who have completed Study M13-550 or Study M13-537 with Upadacitinib (ABT-494)
and has not developed any discontinuation criteria.

2. If the subject has evidence of new latent Tuberculosis (TB) infection, the subject
must initiate and complete a minimum of 2 weeks (or per local guidelines, whichever is
longer) of an ongoing TB prophylaxis before continuing to receive study drug.

3. If female, subject must meet one of the following criteria:

- Postmenopausal (defined as no menses for at least 1 year).

- Surgically sterile (bilateral oophorectomy or hysterectomy).

- Practicing from the time of screening until at least 30 days after the last dose
of study drug at least TWO of the following methods of birth control:

1. Tubal ligation

2. Partner vasectomy (at least 6 months earlier) (the vasectomized male partner
should be the sole partner for that female subject)

3. Intrauterine device

4. A male condom with spermicidal jelly or cream

5. Diaphragm, contraceptive sponge or cervical cap with spermicidal jelly or
cream

6. Hormonal contraceptives (injected, oral, transdermal or implanted methods)
must have been taking at least 2 months prior to dosing

4. Male subjects must agree to follow protocol-specified pregnancy avoidance measures,
including refraining from donating sperm, for up to 30 days post last dose of study
drug.

5. Subjects must voluntarily sign and date an informed consent, approved by an
Independent Ethics Committee (IEC)/Institutional Review Board (IRB), prior to the
initiation of any screening or study specific procedures.

Substudy:

1. Must currently be enrolled in the main study.

2. Must have been receiving a stable dose of upadacitinib (either 15 mg QD or 30 mg QD)
for a minimum of 4 weeks prior to the Vaccination visit.

3. Must have been on a stable dose of background methotrexate (no change in dose or
frequency) for a minimum of 4 weeks prior to the Vaccination visit.

4. If subject is on corticosteroids, must remain on a stable dose of ≤ 10 mg/day of
prednisone or equivalent corticosteroid therapy for at least 4 weeks after the
vaccination visit.

5. Must meet the prescribing specifications as per local label requirements to receive
Prevnar 13® vaccine.

6. Willing to receive Prevnar13® vaccine.

Exclusion Criteria:

1. Pregnant or breastfeeding female.

2. Ongoing infections at Week 0 that have NOT been successfully treated. Subjects with
ongoing infections undergoing treatment may be enrolled BUT NOT dosed until the
infection has been successfully treated.

3. Anticipated requirement or receipt of any live vaccine during study participation
including up to 30 days after the last dose of study drug.

4. Laboratory values from the visit immediately prior to Baseline Visit (local
requirements may apply) meeting the following criteria:

- Serum aspartate transaminase (AST) or alanine transaminase (ALT) > 3.0 × Upper
Limit of Normal (ULN)

- Estimated glomerular filtration rate by simplified 4-variable Modification of
Diet in Renal Disease (MDRD) formula < 40mL/min/1.73m2

- Total white blood cell count (WBC) < 2,000/μL

- Absolute neutrophil count (ANC) < 1,000/μL

- Platelet count < 50,000/μL

- Absolute lymphocytes count < 500/μL

- Hemoglobin < 8 gm/dL

5. Enrollment in another interventional clinical study while participating in this study.

6. Consideration by the investigator, for any reason, that the subject is an unsuitable
candidate to receive study drug.

Substudy:

1. Receiving any csDMARDs other than MTX

2. Receiving > 10 mg/day of prednisone or equivalent corticosteroid therapy.

3. Receipt of any steroid injection within 4 weeks prior to Vaccination visit.

4. History of severe allergic reaction (e.g., anaphylaxis) to any component of Prevnar
13®.

5. History of any documented pneumococcal infection within the last 6 months prior to the
vaccination visit.

6. Receipt of any vaccine 4 weeks prior to the vaccination visit and/or anticipation of
any vaccination for 4 weeks after the vaccination visit.

7. Receipt of any pneumococcal vaccine.

8. Subject is not suitable for the sub-study as per the Investigator's judgment.