FMT in Ulcerative Colitis-Associated Pouchitis

The purpose of this study is to test whether Fecal Microbiota Transplant (FMT) is a safe and
effective treatment for people who have Ulcerative Colitis and have had an ileal pouch
anastomosis.

Ulcerative colitis (UC) is a type of inflammatory bowel disease (IBD) that may be caused by a
person's immune system responding in an unusual way to bacteria normally found in the gut.
Studies have shown that the gut bacteria in people with ulcerative colitis (UC) are different
from the gut bacteria in people without ulcerative colitis (UC). Often, people with
ulcerative colitis (UC) have fewer types of bacteria in their gut which can change the way
that person's immune system works.

This study is for people who have had a proctocolectomy with an ileal pouch anastomosis
(IPAA) to treat ulcerative colitis (UC). More than 50% of people who have had an IPAA will
develop a condition called pouchitis. Pouchitis is short or long-term inflammation of the
ileal pouch that was created in order to store waste from your intestines. Patients with
pouchitis are being asked to take part in this study.

Currently, antibiotics, probiotics and prebiotics are used to treat pouchitis. However, it
has been shown that probiotics are not very helpful once the patient stops taking them. In
addition, antibiotics may cause unfavorable side effects. Fecal microbiota transplantation
(FMT) is being studied as another form of treatment for patients with active pouchitis. Fecal
microbiota transplantation (FMT) or "stool transplant" involves receiving a single fecal
enema from someone who has volunteered to donate their stool.

There are two purposes of this research study:

1. To see whether or not fecal microbiota transplantation (FMT) is a useful treatment for
patients with ulcerative colitis (UC) associated pouchitis

2. To study the changes within the bacteria in the gut in patients with pouchitis (before
and after study treatment) using stool, blood and urine samples