The Effects of Modified Ultrafiltration on Vancomycin Levels During Cardiopulmonary Bypass in Cardiac Surgery
| Status: | Completed |
|---|---|
| Conditions: | Infectious Disease |
| Therapuetic Areas: | Immunology / Infectious Diseases |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/21/2016 |
| Start Date: | April 2014 |
| End Date: | April 2015 |
Antibiotics are routinely used to prevent surgical wound infection. Vancomycin is a widely
used antibiotic for surgery in patients with an allergy to penicillin. During cardiac
surgery, cardiopulmonary bypass (CPB) and modified ultrafiltration (MUF) are routinely used
and can lower the level of the antibiotic. The purpose of this study is to quantify the
change in plasma vancomycin concentration associated with cardiopulmonary bypass and
modified ultrafiltration.
used antibiotic for surgery in patients with an allergy to penicillin. During cardiac
surgery, cardiopulmonary bypass (CPB) and modified ultrafiltration (MUF) are routinely used
and can lower the level of the antibiotic. The purpose of this study is to quantify the
change in plasma vancomycin concentration associated with cardiopulmonary bypass and
modified ultrafiltration.
Subjects having cardiac surgery in which they will be on a heart-lung machine and will
receive the antibiotic vancomycin, will be able to participate.
Up to ten blood samples testing for vancomycin concentrations will be collected in subjects
administered vancomycin as prophylaxis before cardiac surgery with cardiopulmonary bypass
and modified ultrafiltration. Participation will be complete once the cardiac surgery has
been finished.
receive the antibiotic vancomycin, will be able to participate.
Up to ten blood samples testing for vancomycin concentrations will be collected in subjects
administered vancomycin as prophylaxis before cardiac surgery with cardiopulmonary bypass
and modified ultrafiltration. Participation will be complete once the cardiac surgery has
been finished.
Inclusion Criteria:
- Scheduled to undergo cardiac surgery with cardiopulmonary bypass and modified
ultrafiltration
- age greater than 18 years old
- penicillin allergy or in-hospital stay greater than 24 hours
- normal renal function
- normal liver function
- absence of clinical and laboratory signs of infection
Exclusion Criteria:
- vancomycin allergy
- pregnancy
- impaired renal function
- impaired liver function
- morbid obesity
- active infections
- Jehovah's Witness
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