Oxytocin in Opiate Dependence: A Pilot Study of the Effects of Intranasal Oxytocin on Emotional Processes and Stress Responses in Patients With Opiate Dependence

Inclusion Criteria:

- adult men 18 years or older

- meet DSM-IV criteria for opiate dependence, and no other active substance dependence
disorder save nicotine dependence

- clinically stable, and low risk for suicide as determined by principal investigator
and screening questionnaire

- abstinent from non-prescribed opiate use for at least two weeks from Baseline 1 and
free from opiate withdrawal symptoms. If on agonist therapy, dose must be stable for
2 weeks before study visit.

- must be able to use nasal spray

- negative salivary drug screen, save for opiates

Exclusion Criteria:

- any active medical condition that in the opinion of the investigator will interfere
with the objectives of the study

- any active, severe mental illness, neurological disorder, including schizophrenia,
autism, Asperger's syndrome

- are unsuitable in any way to participate in this study, in the opinion of the
investigator

- hospitalizations due to complications of an Axis 1 disorder for the past 12 months,
excluding drug or alcohol rehabilitation

- any clinically significant chronic pain condition, as determined by the principal
investigator

- positive salivary drug screen at the time of the visit, for any substance other than
opiates or another prescribed medication