Utility of Presepsin in Distinguishing Between Sepsis and SIRS
| Status: | Completed |
|---|---|
| Conditions: | Infectious Disease, Hospital |
| Therapuetic Areas: | Immunology / Infectious Diseases, Other |
| Healthy: | No |
| Age Range: | 21 - Any |
| Updated: | 8/23/2018 |
| Start Date: | January 2014 |
| End Date: | July 2015 |
Utility of Presepsin in Distinguishing Between Sepsis and SIRS (Systemic Inflammatory Response Syndrome): an Exploratory, Prospective Observational Study in Critically Ill Patients
This is an observational study to evaluate the diagnostic accuracy of presepsin levels to
discriminate between sepsis and SIRS upon presentation with critical illness compatible with
either sepsis or systemic inflammatory response syndrome (SIRS).
discriminate between sepsis and SIRS upon presentation with critical illness compatible with
either sepsis or systemic inflammatory response syndrome (SIRS).
Sepsis/SIRS Patients
Inclusion Criteria:
- Male or female aged ≥ 21 years
- Appropriate clinical data to enable classification into sepsis or SIRS
- Written informed consent by the patient or legally authorized representative
- Critical illness consistent with SIRS or sepsis, to be enrolled within 18 hours of
presentation
Exclusion Criteria:
- No informed consent
- Unacceptable risk imposed by extra blood sampling, such as by gross hemorrhage with a
hematocrit < 20%
Control
Inclusion Criteria:
- Male or female aged ≥ 21 years
- Does not meet clinical criteria for sepsis or SIRS
- Written informed consent by the patient or legally authorized representative
Exclusion Criteria:
- No informed consent
- Unacceptable risk imposed by extra blood sampling, such as by gross hemorrhage with a
hematocrit < 20%
End Stage Renal Disease
Inclusion Criteria:
- Male or female aged ≥ 21 years
- Documented diagnosis of end stage renal disease currently undergoing dialysis
- Does not meet clinical criteria for sepsis or SIRS
- Written informed consent by the patient or legally authorized representative
Exclusion Criteria:
- No informed consent
- Unacceptable risk imposed by extra blood sampling, such as by gross hemorrhage with a
hematocrit < 20%
We found this trial at
2
sites
Tufts Medical Center Tufts Medical Center is an internationally-respected academic medical center – a teaching...
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